{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:32:23Z","timestamp":1784255543825,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Brian White ALS Research Foundation"},{"name":"NIH","award":["K23NS06289223 (MSC)"],"award-info":[{"award-number":["K23NS06289223 (MSC)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Muscle cramping is a common symptom in amyotrophic lateral sclerosis (ALS) that lacks efficacious treatment. The natural history of this symptom is unknown, which hampers efforts to design optimal clinical trials. <jats:italic>Methods<\/jats:italic>: We surveyed early stage ALS patients about their experience with cramps each month by phone for up to 21 months. <jats:italic>Results<\/jats:italic>: Cramps developed in 95% of patients over the course of their disease. The number of cramps experienced by an individual varied widely from month\u2010to\u2010month and trended lower after the first year of illness (<jats:italic>P<\/jats:italic> = 0.26). Those with limb\u2010onset and age &gt;60 years had more cramps than bulbar\u2010onset (<jats:italic>P<\/jats:italic> &lt; 0.0001) and younger patients (<jats:italic>P<\/jats:italic> &lt; 0.0001). <jats:italic>Conclusions<\/jats:italic>: The high variability of the number of cramps experienced suggests that clinical trials will need to use crossover designs or large numbers of participants, even when the treatment effect is substantial. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>53<\/jats:bold>: 513\u2013517, 2016<\/jats:p>","DOI":"10.1002\/mus.24892","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T21:38:17Z","timestamp":1441229897000},"page":"513-517","source":"Crossref","is-referenced-by-count":54,"title":["Natural history of muscle cramps in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"53","author":[{"given":"James B.","family":"Caress","sequence":"first","affiliation":[{"name":"Department of Neurology Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Ciarlone","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology Morsani College of Medicine University of South Florida Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Neurology Associates Hattiesburg Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah P.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Cartwright","sequence":"additional","affiliation":[{"name":"Department of Neurology Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03540.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1434"},{"key":"e_1_2_7_4_1","first-page":"A199","article-title":"The spectrum of patient symptoms in ALS and symptom management","volume":"56","author":"Heiman\u2010Patterson TD","year":"2001","journal-title":"Neurology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.7.1316"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-6567-6_71"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bc01a4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960802430773"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.200642"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14660820310017344"},{"key":"e_1_2_7_11_1","first-page":"1","article-title":"Treatment for cramps in amyotrophic lateral sclerosis\/motor neuron disease","volume":"4","author":"Baldinger R","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_7_13_1","first-page":"13","article-title":"The ALSFRS\u2010R: a revised ALS functional rating scale that incorporates assessments of respiratory function","volume":"169","author":"Cedarbaum JM","year":"1999","journal-title":"J Neurosci"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199704000-00003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-6567-6_20"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2011.11.026"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608201300079364"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.6.1383"},{"key":"e_1_2_7_19_1","unstructured":"Oskarsson B.2014.ClinicalTrials.gov: mexiletine for the treatment of muscle cramps in ALS. Available athttps:\/\/clinicaltrials.gov\/ct2\/show\/NCT01811355. Accessed March 19 2015."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199403033300901"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150200071"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24892","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:08:11Z","timestamp":1695492491000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,28]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1002\/mus.24892"],"URL":"https:\/\/doi.org\/10.1002\/mus.24892","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,28]]}}}