{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T01:29:34Z","timestamp":1783214974443,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation Competitive Research Program","award":["NRF-CRP10-2012-01"],"award-info":[{"award-number":["NRF-CRP10-2012-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>A long\u2010term peripheral neural interface is an area of intense research. The use of electrode interfaces is limited by the biological response to the electrode material.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We created an electrode construct to harbor the rat sciatic nerve with interposition of autogenous adipose tissue between the nerve and the electrode. The construct was implanted for 10 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunohistochemistry showed a unique laminar pattern of axonal growth layered between fibro\u2010collagenous tissue, forming a physical interface with the tungsten micro\u2010electrode. Action potentials transmitted across the intrerface showed mean conduction velocities varying between 6.99\u2009\u00b1\u20092.46 and 20.14\u2009\u00b1\u20094 m\/s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have demonstrated the feasibility of a novel peripheral nerve interface through modulation of normal biologic phenomena. It has potential applications as a chronic implantable neural interface. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>53<\/jats:bold>: 789\u2013796, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.24928","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T23:52:41Z","timestamp":1443743561000},"page":"789-796","source":"Crossref","is-referenced-by-count":8,"title":["Self\u2010organization of \u201cfibro\u2010axonal\u201d composite tissue around unmodified metallic micro\u2010electrodes can form a functioning interface with a peripheral nerve: A new direction for creating long\u2010term neural interfaces"],"prefix":"10.1002","volume":"53","author":[{"given":"Amitabha","family":"Lahiri","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio Martinez","family":"Delgado","sequence":"additional","affiliation":[{"name":"Singapore Institute for Neurotechnology  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swathi","family":"Sheshadri","sequence":"additional","affiliation":[{"name":"Singapore Institute for Neurotechnology  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian\u2010Ann","family":"Ng","sequence":"additional","affiliation":[{"name":"Singapore Institute for Neurotechnology  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudip","family":"Nag","sequence":"additional","affiliation":[{"name":"Singapore Institute for Neurotechnology  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Cheng","family":"Yen","sequence":"additional","affiliation":[{"name":"Singapore Institute for Neurotechnology  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitish V.","family":"Thakor","sequence":"additional","affiliation":[{"name":"Singapore Institute for Neurotechnology  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199709000-00003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199701000-00004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050907"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1114\/1.1569263"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2004.827535"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2003.820321"},{"key":"e_1_2_6_8_1","first-page":"91","article-title":"Stimulation and recording from regenerated peripheral nerves through polyimide sieve electrodes","volume":"3","author":"Navarro X","year":"1998","journal-title":"J Peripher Nerv Syst"},{"key":"e_1_2_6_9_1","first-page":"151","article-title":"Peripheral nerve regeneration through microelectrode arrays based on silicon technology","volume":"9","author":"Navarro X","year":"1996","journal-title":"Restor Neurol Neurosci"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.10099"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2005.10303.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90667-C"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199812)21:12<1748::AID-MUS18>3.0.CO;2-K"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284431051006510"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-1-00305.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000121425.42966.F1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31824a2b19"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1478"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000066"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000097"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1997.19110023.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90314-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00238-012-0728-9"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e318295de95"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000000126"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-32.1.1"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24171"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1556\/APhysiol.88.2001.3-4.6"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3887"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24928","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T08:30:21Z","timestamp":1696494621000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,19]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1002\/mus.24928"],"URL":"https:\/\/doi.org\/10.1002\/mus.24928","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,19]]}}}