{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:36:11Z","timestamp":1771472171249,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"State of Bavaria"},{"DOI":"10.13039\/501100008769","name":"University of W\u00fcrzburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008769","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Union's Seventh Framework Programme \u201cncRNAPain\u201d","award":["602133"],"award-info":[{"award-number":["602133"]}]},{"name":"W\u00fcrzburg University Medical School"},{"name":"ENS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Sural nerve biopsy is an important means of establishing the diagnosis of inflammatory neuropathies. We investigated the diagnostic value of endoneurial edema. <jats:italic>Methods<\/jats:italic>: Diagnostic sural nerve biopsies from 42 patients with inflammatory and 28 patients with noninflammatory neuropathies were re\u2010evaluated for the presence of endoneurial edema. Edema was assessed on hematoxylin\u2010eosin stained paraffin and frozen sections and on azure II\u2010methylene blue stained semithin sections. We determined the area of endoneurial edema on digitized images in relation to the entire endoneurial area of each fascicle. <jats:italic>Results<\/jats:italic>: Edema was more extensive in neuropathies with short disease duration (\u226412 months) as compared to long duration (&gt;12 months; <jats:italic>P\u2009&lt;\u2009<\/jats:italic>0.01). Edema in inflammatory neuropathies of \u226412 months duration covered a larger area than in noninflammatory neuropathies (<jats:italic>P\u2009&lt;\u2009<\/jats:italic>0.01), and the extent of edema correlated negatively with disease duration (<jats:italic>P\u2009&lt;\u2009<\/jats:italic>0.05). <jats:italic>Conclusions<\/jats:italic>: Endoneurial edema may be a useful additional disease marker in inflammatory neuropathies of recent onset. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>53<\/jats:bold>: 705\u2013710, 2016<\/jats:p>","DOI":"10.1002\/mus.24930","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T23:16:42Z","timestamp":1444173402000},"page":"705-710","source":"Crossref","is-referenced-by-count":28,"title":["Endoneurial edema in sural nerve may indicate recent onset inflammatory neuropathy"],"prefix":"10.1002","volume":"53","author":[{"given":"Nurcan","family":"\u00dc\u00e7eyler","sequence":"first","affiliation":[{"name":"Department of Neurology University of W\u00fcrzburg Josef\u2010Schneider\u2010Str. 11 97080 W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Necula","sequence":"additional","affiliation":[{"name":"Department of Neurology University of W\u00fcrzburg Josef\u2010Schneider\u2010Str. 11 97080 W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Wagemann","sequence":"additional","affiliation":[{"name":"Department of Neurology University of W\u00fcrzburg Josef\u2010Schneider\u2010Str. 11 97080 W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus V.","family":"Toyka","sequence":"additional","affiliation":[{"name":"Department of Neurology University of W\u00fcrzburg Josef\u2010Schneider\u2010Str. 11 97080 W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Neurology University of W\u00fcrzburg Josef\u2010Schneider\u2010Str. 11 97080 W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000188879.19900.b7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2011.00301.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2007.08.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20076"},{"key":"e_1_2_6_7_1","first-page":"185","article-title":"The immune system in neurologic disease: selected recent developments","volume":"96","author":"Toyka KV","year":"1996","journal-title":"Acta Neurol Belg"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1088"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23821"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328363bfa4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00290.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.5.636"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0275-9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7216-9491-7.50035-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390308"},{"key":"e_1_2_6_17_1","first-page":"19","article-title":"Histopathological evaluation of inflammatory & hereditary demyelinating polyneuropathies","volume":"107","author":"Menon A","year":"1998","journal-title":"Indian J Med Res"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00695502"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00822-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294303"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-302312"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(00)00323-4"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(92)90134-7"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00401-002-0607-8","article-title":"Matrix metalloproteinases\u20109 and \u20102 in secondary vasculitic neuropathies","volume":"105","author":"Renaud S","year":"2003","journal-title":"Acta Neuropathol"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.1.62"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430404"}],"container-title":["Muscle &amp; 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