{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:51:57Z","timestamp":1791179517352,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Cold\u2010induced sweating syndrome type 1 (CISS1), is a rare, severe, autosomal recessive disease. It is characterized by morphological alterations and profuse sweating when ambient temperature is &lt;22\u2009\u00b0C. Although some individuals with CISS1 have decreased pain perception, no study has been conducted to evaluate thermal and pain sensations in these patients. The aim of this study was to assess the function of the nociceptive A\u03b4\u2010fibers and warmth C\u2010fibers by using CO\n                      <jats:sub>2<\/jats:sub>\n                      laser\u2010evoked potentials (LEPs) in patients affected by CISS1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four patients were studied. Laser pulses were applied to the skin of the right hand and the perioral region at painful intensity to record A\u03b4\u2010LEPs, and at non\u2010painful intensity to obtain C\u2010LEPs. Fifteen healthy subjects were studied for control purposes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant difference in latencies or amplitudes of either A\u03b4\u2010 or C\u2010LEPs was found between the 2 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Cutaneous nociceptive and warmth pathway functions are normal in CISS1.\n                      <jats:italic>Muscle Nerve<\/jats:italic>\n                      <jats:bold>54<\/jats:bold>\n                      : 100\u2013103, 2016\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.24976","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T11:06:42Z","timestamp":1447412802000},"page":"100-103","source":"Crossref","is-referenced-by-count":0,"title":["Warmth and nociceptive evoked potentials in cold\u2010induced sweating syndrome type 1"],"prefix":"10.1002","volume":"54","author":[{"given":"Elisa","family":"Testani","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Neurosciences and Orthopedics Catholic University, Policlinico Universitario \u201cA. Gemelli,\u201d Largo Agostino Gemelli No. 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Della Marca","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Neurosciences and Orthopedics Catholic University, Policlinico Universitario \u201cA. Gemelli,\u201d Largo Agostino Gemelli No. 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"La Torraca","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Catholic University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catello","family":"Vollono","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Neurosciences and Orthopedics Catholic University, Policlinico Universitario \u201cA. Gemelli,\u201d Largo Agostino Gemelli No. 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giangiorgio","family":"Crisponi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Clinical Medicine, Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Zampino","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Catholic University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Valeriani","sequence":"additional","affiliation":[{"name":"Neurology Division, Pediatric Hospital \u201cBambino Ges\u00f9\u201d IRCCS Rome Italy"},{"name":"Center for Sensory\u2010Motor Interaction Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/513608"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<365::AID-AJMG8>3.0.CO;2-Q"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/346120"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.07.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/516843"},{"key":"e_1_2_6_7_1","first-page":"1993","volume-title":"GeneReviews [internet]","author":"Hahn AF"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.00791.x"},{"key":"e_1_2_6_9_1","first-page":"33","article-title":"Nerve fibre discharges, cerebral potentials and sensations induced by CO2 laser stimulation","volume":"3","author":"Bromm B","year":"1984","journal-title":"Hum Neurobiol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.02969.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2012.05.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f96237"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.126"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03630.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.253"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.24976","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24976","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.24976","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:02:02Z","timestamp":1791176522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,26]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/mus.24976"],"URL":"https:\/\/doi.org\/10.1002\/mus.24976","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,26]]}}}