{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T20:47:10Z","timestamp":1748983630958},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172874"],"award-info":[{"award-number":["81172874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label \/><jats:p><jats:italic>Introduction<\/jats:italic>: Chemokine CC motif receptors 9 and 7 (CCR9 and CCR7) play a major role in the migration of T\u2010cell precursors to the thymus to initiate T thymopoiesis. However, their role in development of T\u2010cells in myasthenia gravis (MG) patients has not been fully elucidated. <jats:italic>Methods<\/jats:italic>: Expression and distribution of CCR9<jats:sup>+<\/jats:sup> and CCR7<jats:sup>+<\/jats:sup> cells were detected by flow cytometry and immunofluorescence. Real\u2010time polymerase chain reaction was used to check the adhesion molecules on CD4<jats:sup>\u2013<\/jats:sup>CD8<jats:sup>\u2013<\/jats:sup> double\u2010negative (DN) thymocytes. <jats:italic>Results<\/jats:italic>: CCR9 and CCR7 expression by DN thymocytes increased in the MG thymus; the levels of CCR9, CCR7, interleukin\u20107R mRNA increased, and CXCR4 levels decreased compared with levels in the non\u2010MG thymus. More CCR7 and CCR9 double\u2010positive (DP) thymocytes were gathered near the subcapsular region in MG thymus. <jats:italic>Conclusions<\/jats:italic>: Enhanced expression of CCR9 and CCR7 may complicate the differentiation of DP thymocytes from the DN stage in MG thymus. <jats:italic>Muscle Nerve<\/jats:italic>, 2016 <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>55<\/jats:bold>: 84\u201390, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.24999","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T09:56:44Z","timestamp":1448877404000},"page":"84-90","source":"Crossref","is-referenced-by-count":4,"title":["CCR9 AND CCR7 are overexpressed in CD4<sup>\u2013<\/sup>CD8<sup>\u2013<\/sup> thymocytes of myasthenia gravis patients"],"prefix":"10.1002","volume":"55","author":[{"given":"Qianru","family":"Li","sequence":"first","affiliation":[{"name":"Department of Immunology, Basic Medical College Zhengzhou University No.100 of Science Road, Zhengzhou 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