{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:37:37Z","timestamp":1775536657375,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle Nerve"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1002\/mus.25009","type":"journal-article","created":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T03:40:19Z","timestamp":1449978019000},"page":"165-168","source":"Crossref","is-referenced-by-count":19,"title":["Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine"],"prefix":"10.1002","volume":"53","author":[{"given":"Ted M.","family":"Burns","sequence":"first","affiliation":[{"name":"Department of Neurology; University of Virginia; Charlottesville Virginia 22908 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah; Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Minnesota; Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony A.","family":"Amato","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women's Hospital; Harvard Medical School; Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. David","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Neurology and Physical Medicine and Rehabilitation; Ohio State University; Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Barohn","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Kansas; Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Benatar","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Miami; Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn J.","family":"Bird","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Pennsylvania; Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Bromberg","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah; Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizar","family":"Chahin","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Connecticut; Farmington Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Ciafaloni","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Rochester; Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Neurology; Geisel School of Medicine at Dartmouth; Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Corse","sequence":"additional","affiliation":[{"name":"Department of Neurology; The Johns Hopkins University School of Medicine; Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian A.","family":"Crum","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S.","family":"David","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital; Harvard Medical School; Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot","family":"Dimberg","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo A. De","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Oklahoma; Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Donofrio","sequence":"additional","affiliation":[{"name":"Department of Neurology; Vanderbilt University; Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. James B.","family":"Dyck","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G.","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik R.","family":"Ensrud","sequence":"additional","affiliation":[{"name":"Department of Neurology; Boston Veterans Affairs; Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Tennessee Health Science Center; Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Freimer","sequence":"additional","affiliation":[{"name":"Department of Neurology; Ohio State University; Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karissa L.","family":"Gable","sequence":"additional","affiliation":[{"name":"Department of Neurology; Duke University; Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Summer","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah; Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Gilchrist","sequence":"additional","affiliation":[{"name":"Department of Neurology; Southern Illinois University School of Medicine; Springfield Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Neurology; Hospital for Special Surgery; New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifton L.","family":"Gooch","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of South Florida; Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent P.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Scottsdale Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitri","family":"Gorelov","sequence":"additional","affiliation":[{"name":"Crystal Run Healthcare; Middletown New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Sidney M.","family":"Gospe","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Washington; Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namita A.","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of California Irvine; Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda C.","family":"Guidon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital; Harvard Medical School; Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey T.","family":"Guptill","sequence":"additional","affiliation":[{"name":"Department of Neurology; Duke University; Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Gutmann","sequence":"additional","affiliation":[{"name":"Division of Neurology; University of Iowa; Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludwig","family":"Gutmann","sequence":"additional","affiliation":[{"name":"Division of Neurology; University of Iowa; Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Gwathmey","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Virginia; Charlottesville Virginia 22908 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadollah","family":"Harati","sequence":"additional","affiliation":[{"name":"Department of Neurology; Baylor College of Medicine; Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"C. Michel","family":"Harper","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.","family":"Hehir","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Vermont; Burlington Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa D.","family":"Hobson-Webb","sequence":"additional","affiliation":[{"name":"Department of Neurology; Duke University; Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"James F.","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of North Carolina; Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlayne E.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Neurology and Otolaryngology; University of Texas Health Science Center; San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah; Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Virginia; Charlottesville Virginia 22908 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vern C.","family":"Juel","sequence":"additional","affiliation":[{"name":"Department of Neurology; Duke University; Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry J.","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Department of Neurology; George Washington University; Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chafic","family":"Karam","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of North Carolina; Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen D.","family":"Kennelly","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami","family":"Khella","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Pennsylvania; Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Neurology; Oregon Health Science University; Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Kincaid","sequence":"additional","affiliation":[{"name":"Department of Neurology; Indiana University; Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Kissel","sequence":"additional","affiliation":[{"name":"Department of Neurology; Ohio State University; Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah","family":"Kolb","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah; Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lacomis","sequence":"additional","affiliation":[{"name":"Department of Neurology and Pathology; University of Pittsburgh; Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shafeeq","family":"Ladha","sequence":"additional","affiliation":[{"name":"Department of Neurology; Barrow Neurological Institute; Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Larriviere","sequence":"additional","affiliation":[{"name":"Department of Neurology; Ochsner Neuroscience Institute; New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Neurology; Cedars-Sinai Medical Center; Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuebing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology; Cleveland Clinic; Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Litchy","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Logigian","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Rochester; Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jau-Shin","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of North Dakota, Sanford Health; Fargo North Dakota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.L.","family":"MacGowen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Department of Neurology; Mount Sinai Beth Israel Hospital; New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Maselli","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of California, Davis; Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice M.","family":"Massey","sequence":"additional","affiliation":[{"name":"Department of Neurology; Duke University; Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle L.","family":"Mauermann","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine D.","family":"Mathews","sequence":"additional","affiliation":[{"name":"Division of Neurology; University of Iowa; Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew N.","family":"Meriggioli","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences; Rush University Medical Center; Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Neurosciences; California Pacific Medical Center; San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon-Shik","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Oklahoma; Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahseen","family":"Mozaffar","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of California Irvine; Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon P.","family":"Nations","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurotherapeutics; University Texas Southwestern; Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Neurology; Yale School of Medicine; New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyle W.","family":"Ostrow","sequence":"additional","affiliation":[{"name":"Department of Neurology; The Johns Hopkins University School of Medicine; Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Pascuzzi","sequence":"additional","affiliation":[{"name":"Department of Neurology; Indiana University; Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Peltier","sequence":"additional","affiliation":[{"name":"Department of Neurology; Vanderbilt University; Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Ruzhansky","sequence":"additional","affiliation":[{"name":"Department of Neurology; Medical University of South Carolina; Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Richman","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of California, Davis; Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Scottsdale Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DEVON I.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Neurology; Lahey Hospital and Medical Center; Burlington Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George M.","family":"Sachs","sequence":"additional","affiliation":[{"name":"Department of Neurology; Alpert Medical School of Brown University; Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Kian","family":"Salajegheh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women's Hospital; Harvard Medical School; Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Saperstein","sequence":"additional","affiliation":[{"name":"Phoenix Neurological Associates; Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Scelsa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Department of Neurology; Mount Sinai Beth Israel Hospital; New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duygu","family":"Selcen","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziz","family":"Shaibani","sequence":"additional","affiliation":[{"name":"Nerve and Muscle Center of Texas; Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perry B.","family":"Shieh","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of California at Los Angeles; Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Buffalo; Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Rob","family":"Singleton","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Utah; Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benn E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Scottsdale Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuen T.","family":"So","sequence":"additional","affiliation":[{"name":"Department of Neurology; Stanford University; Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Solorzano","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Virginia; Charlottesville Virginia 22908 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Sorenson","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayashri","family":"Srinivasen","sequence":"additional","affiliation":[{"name":"Department of Neurology; Lahey Hospital and Medical Center; Burlington Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinny","family":"Tavee","sequence":"additional","affiliation":[{"name":"Department of Neurology; Cleveland Clinic; Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabi","family":"Tawil","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Rochester; Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pariwat","family":"Thaisetthawatkul","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Nebraska; Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Thornton","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Rochester; Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Neurology; Yale School of Medicine; New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Vernino","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurotherapeutics; University Texas Southwestern; Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabel K.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology; Veterans Affairs Long Beach Healthcare System; Long Beach California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler A.","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Oklahoma; Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Washington; Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Windebank","sequence":"additional","affiliation":[{"name":"Department of Neurology; Mayo Clinic; Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gil I.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Neurology; University of Buffalo; Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"10.1002\/mus.25009-BIB0001|mus25009-cit-0001","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1136\/jnnp.46.7.684","article-title":"Novel drug of choice in Eaton-Lambert syndrome","volume":"46","author":"Lundh","year":"1983","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1002\/mus.25009-BIB0002|mus25009-cit-0002","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJM198912073212303","article-title":"3,4-Diaminopyridine in the treatment of Lambert-Eaton myasthenic syndrome","volume":"321","author":"McEvoy","year":"1989","journal-title":"New Engl J Med"},{"key":"10.1002\/mus.25009-BIB0003|mus25009-cit-0003","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1212\/WNL.54.3.603","article-title":"A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome","volume":"54","author":"Sanders","year":"2000","journal-title":"Neurology"},{"key":"10.1002\/mus.25009-BIB0004|mus25009-cit-0004","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/mus.21422","article-title":"3,4-Diaminopyridine is more effective than placebo in a randomized, double-blind, cross-over drug study in LEMS","volume":"40","author":"Oh","year":"2009","journal-title":"Muscle Nerve"},{"key":"10.1002\/mus.25009-BIB0005|mus25009-cit-0005","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/clpt.2009.35","article-title":"Efficacy of 3,4-diaminopyridine and pyridostigmine in the treatment of Lambert-Eaton myasthenic syndrome: a randomized, double-blind, placebo-controlled, crossover study","volume":"86","author":"Wirtz","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"10.1002\/mus.25009-BIB0006|mus25009-cit-0006","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ana.23672","article-title":"consortia of the rare disease clinical research network","volume":"72","author":"Murphy","year":"2012","journal-title":"Ann Neurol"},{"key":"10.1002\/mus.25009-BIB0007|mus25009-cit-0007","unstructured":"European Medicines Agency Assessment report for Zenas [online] http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Public_assessment_report\/human\/001032\/WC500069918.pdf\/ 2015"},{"key":"10.1002\/mus.25009-BIB0008|mus25009-cit-0008","doi-asserted-by":"crossref","first-page":"c6466","DOI":"10.1136\/bmj.c6466","article-title":"Open letter to prime minister David Cameron and Andrew Lansley","volume":"341","author":"Nicholl","year":"2010","journal-title":"BMJ"},{"key":"10.1002\/mus.25009-BIB0009|mus25009-cit-0009","unstructured":"East Midlands Specialised Commissioning Group 3,4 Diaminopyridine (phosphate form) (Firdapse\u00ae) for treatment of Lambert-Eaton myasthenic syndrome and congenital myasthenia syndromes 2015 http:\/\/www.emscg.nhs.uk\/library\/emscgp038v1policyfirdapse050711.pdf"},{"key":"10.1002\/mus.25009-BIB0010|mus25009-cit-0010","doi-asserted-by":"crossref","unstructured":"Oh SJ Firdapse\u00ae (Amiframpridine or 3,4-diaminopyridine phosphate) is safe and effective in a pivotal phase 3 trial in LEMS patients 2015","DOI":"10.1212\/WNL.84.14_supplement.PL2.001"},{"key":"10.1002\/mus.25009-BIB0011|mus25009-cit-0011","doi-asserted-by":"crossref","unstructured":"Sanders , DB Juel VC Harati Y Smith AG Peltier AC Marburger T et al Results of a double-blind placebo-controlled withdrawal study of 3,4-diaminopyridine (DAP) in Lambert-Eaton myasthenic syndrome (LEMS) 2015","DOI":"10.1212\/WNL.82.10_supplement.P4.271"},{"key":"10.1002\/mus.25009-BIB0012|mus25009-cit-0012","unstructured":"https:\/\/www.aan.com\/uploadedFiles\/Website_Library_Assets\/Documents\/8.Membership\/5.Ethics\/1.Code_of_Conduct\/Membership-Ethics-American%20Academy%20of%20Neurology%20Code%20of%20Professional%20Conduct%20(2).pdf\/ 2015"},{"key":"10.1002\/mus.25009-BIB0013|mus25009-cit-0013","doi-asserted-by":"crossref","unstructured":"Nass SJ Patlak M Ensuring patient access to affordable cancer drugs; workshop summary. 2014. Institute of Medicine of the National Academies http:\/\/www.nap.edu\/catalog\/18956\/ensuring-patient-access-to-affordable-cancer-drugs-workshop-summary\/ 2015","DOI":"10.17226\/18956"},{"key":"10.1002\/mus.25009-BIB0014|mus25009-cit-0014","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.mayocp.2015.06.001","article-title":"In support of a patient-driven initiative and petition to lower the high price of cancer drugs","volume":"90","author":"Tefferi","year":"2015","journal-title":"Mayo Clin Proc"},{"key":"10.1002\/mus.25009-BIB0015|mus25009-cit-0015","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1056\/NEJMp1513227","article-title":"A delicate balance-pharmaceutical innovation and access","volume":"373","author":"Chin","year":"2015","journal-title":"N Engl J Med"}],"container-title":["Muscle & Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.25009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.25009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/mus.25009\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T01:00:03Z","timestamp":1718240403000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.25009"}},"subtitle":["Editorial"],"short-title":[],"issued":{"date-parts":[[2015,12,21]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"URL":"https:\/\/doi.org\/10.1002\/mus.25009","archive":["Portico"],"relation":{},"ISSN":["0148-639X"],"issn-type":[{"value":"0148-639X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12,21]]}}}