{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:41:53Z","timestamp":1774316513262,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T00:00:00Z","timestamp":1453248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Stimulated jitter analysis (stim\u2010JA) using a concentric needle electrode is a technique used to study the neuromuscular junction (NMJ) without voluntary activation. Our objective was to study the diagnostic sensitivity, specificity, and feasibility of stim\u2010JA in infants and children with suspected NMJ defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen infants and young children ages 2 months to 17 years with suspected NMJ disorders were evaluated using stim\u2010JA over a period of 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subjects with suspected NMJ defects and abnormal stim\u2010JA subsequently had laboratory confirmation of myasthenia gravis (<jats:italic>n<\/jats:italic>\u2009=\u20095) and infant botulism (<jats:italic>n<\/jats:italic>\u2009=\u20092). Turnaround time for confirmatory laboratory tests was 6.0\u2009\u00b1\u20094.3 days, whereas stim\u2010JA results were available immediately. All subjects tolerated stim\u2010JA well without complications or need for sedation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Stim\u2010JA is a sensitive and safe first\u2010line diagnostic test for evaluation of suspected pediatric NMJ disorders. Stim\u2010JA results precede assay results and may guide early treatment. <jats:italic>Muscle Nerve<\/jats:italic> 53: 471\u2013472, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25012","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T15:10:23Z","timestamp":1449933023000},"page":"471-472","source":"Crossref","is-referenced-by-count":17,"title":["Stimulated jitter analysis for the evaluation of neuromuscular junction disorders in children"],"prefix":"10.1002","volume":"53","author":[{"given":"Sumit","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Neurology Emory University School of Medicine 1605 Chantilly Drive NE, Suite 300 Atlanta Georgia 30324 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Lin","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.02038.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20568"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150405"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20637"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.03.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23709"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000161"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24657"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.25012","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.25012","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.25012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:37:43Z","timestamp":1695559063000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.25012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,20]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/mus.25012"],"URL":"https:\/\/doi.org\/10.1002\/mus.25012","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,20]]}}}