{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T17:56:58Z","timestamp":1775671018512,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"SPS KAKENHI Grant-in-Aid for Scientific Research C)","award":["25463459"],"award-info":[{"award-number":["25463459"]}]},{"name":"Joint Program for ALS Research"},{"name":"Tokyo Metropolitan Institute of Medical Science"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p><jats:italic>Introduction<\/jats:italic>: An enlarged tongue (macroglossia) has been reported in advanced\u2010stage patients with amyotrophic lateral sclerosis (ALS). <jats:italic>Methods<\/jats:italic>: In this study we examined the prevalence of macroglossia and analyzed clinical correlations in 65 ALS patients on tracheostomy\u2010invasive ventilation (TIV). <jats:italic>Results<\/jats:italic>: Macroglossia was found in 22 patients (33.8%). Compared with those without macroglossia, patients with macroglossia had a younger age of onset, longer duration of disease and TIV use, lower ALS Functional Rating Scale score, higher body mass index, lower energy intake, more severe communication impairment, and lower oral function. Logistic multivariate analysis showed that body mass index (BMI; <jats:italic>P<\/jats:italic>\u2009=\u20090.007) and communication impairment (<jats:italic>P<\/jats:italic>\u2009=\u20090.029) were significantly correlated with macroglossia. The duration of TIV use was at the cut\u2010off level of significance (<jats:italic>P<\/jats:italic>\u2009=\u20090.05). <jats:italic>Conclusions<\/jats:italic>: Macroglossia may be the result of overfeeding and replacement by fat during long\u2010term TIV use in patients with advanced ALS. <jats:italic>Muscle Nerve<\/jats:italic>, 2016 <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>54<\/jats:bold>: 386\u2013390, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25058","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T23:28:45Z","timestamp":1453937325000},"page":"386-390","source":"Crossref","is-referenced-by-count":19,"title":["Macroglossia in advanced amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"54","author":[{"given":"Chiharu","family":"Matsuda","sequence":"first","affiliation":[{"name":"ALS Nursing Care Project Tokyo Metropolitan Institute of Medical Science 2\u20101\u20106 Kamikitazawa Setagaya\u2010ku Tokyo 156\u20108506 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