{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:52:22Z","timestamp":1791179542522,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T00:00:00Z","timestamp":1463616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T00:00:00Z","timestamp":1463616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Introduction:<\/jats:italic>\n                    Adult\u2010onset Krabbe disease is clinically rare and usually affects the pyramidal tracts in the central nervous system. Patients develop a spastic gait, and peripheral neuropathy sometimes occurs simultaneously.\n                    <jats:italic>Methods:<\/jats:italic>\n                    A 55\u2010year\u2010old woman with consanguineous parents developed slowly progressive, asymmetric muscle weakness and atrophy in her forearms, while her ability to walk remained unaffected without pyramidal tract signs after onset at age 51 years.\n                    <jats:italic>Results:<\/jats:italic>\n                    Nerve conduction studies demonstrated an asymmetric demyelinating\u2010type peripheral neuropathy, and sural nerve biopsy documented reduced myelinated nerve fiber density with uniformly thin myelin sheaths, suggesting hypomyelination. Brain MRI demonstrated minor white\u2010matter injury along the optic radiations, which was associated with asymptomatic, mild, prolonged latency on visual evoked potentials. Laboratory analysis documented low enzyme activity of galactocerebrosidase (GALC) and a known mutation of the\n                    <jats:italic>GALC<\/jats:italic>\n                    gene.\n                    <jats:italic>Conclusion:<\/jats:italic>\n                    Isolated peripheral neuropathy occurs very rarely in adult\u2010onset Krabbe disease.\n                    <jats:italic>Muscle Nerve<\/jats:italic>\n                    <jats:bold>54<\/jats:bold>\n                    : 152\u2013157, 2016\n                  <\/jats:p>","DOI":"10.1002\/mus.25067","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T17:08:51Z","timestamp":1454519331000},"page":"152-157","source":"Crossref","is-referenced-by-count":12,"title":["Adult\u2010onset Krabbe disease presenting with an isolated form of peripheral neuropathy"],"prefix":"10.1002","volume":"54","author":[{"given":"Hiroshi","family":"Adachi","sequence":"first","affiliation":[{"name":"Division of Neurology Hyogo Prefectural Amagasaki General Medical Center 2\u201017\u201077 East\u2010Naniwa Amagasaki City Hyogo 660\u20108550 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Division of Neurology Hyogo Prefectural Amagasaki General Medical Center 2\u201017\u201077 East\u2010Naniwa Amagasaki City Hyogo 660\u20108550 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisatsugu","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Neurology Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Neurology National Hospital Organization Minami Kyoto Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiro","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Neurology and Geriatrics Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Takashima","sequence":"additional","affiliation":[{"name":"Department of Neurology and Geriatrics Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Division of Neurology Hyogo Prefectural Amagasaki General Medical Center 2\u201017\u201077 East\u2010Naniwa Amagasaki City Hyogo 660\u20108550 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasufumi","family":"Kageyama","sequence":"additional","affiliation":[{"name":"Division of Neurology Hyogo Prefectural Amagasaki General Medical Center 2\u201017\u201077 East\u2010Naniwa Amagasaki City Hyogo 660\u20108550 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.66.2.302"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2012.02.023"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-012-9560-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.11.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050573"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.5.1392"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199708)20:8<1024::AID-MUS13>3.0.CO;2-V"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(01)00285-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-012-0956-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2012.08.004"}],"container-title":["Muscle &amp; 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