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This review focuses on SFN involving nociception and temperature, examining epidemiology, etiology, clinical presentation, diagnosis, pathophysiology, and management. Prevalence of SFN is 52.95 per 100,000 population, and diabetes and idiopathic are the most common etiologies. Dysesthesia, allodynia, pain, burning, and coldness sensations frequently present in a length\u2010dependent pattern. Additional autonomic features in gastrointestinal, urinary, or cardiovascular systems are frequent but poorly objectified. SFN is diagnosed by intraepidermal nerve fiber density and quantitative sensory and autonomic tests in combination with normal nerve conduction. Pathophysiological understanding centers on sodium channel dysfunction, and genetic forms are beginning to be understood. Treatment is directed at the underlying etiology supported by symptomatic treatment using antidepressants and anticonvulsants. Little is known about long\u2010term outcomes, and systematic cohort studies are needed. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>53<\/jats:bold>: 671\u2013682, 2016<\/jats:p>","DOI":"10.1002\/mus.25082","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T14:53:49Z","timestamp":1455375229000},"page":"671-682","source":"Crossref","is-referenced-by-count":131,"title":["Small fiber neuropathy: Getting bigger!"],"prefix":"10.1002","volume":"53","author":[{"given":"Amanda C.Y.","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Neurology National University Hospital Level 10 Tower Block, University Medicine Cluster, 1E Kent Ridge Road 119228 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einar P.","family":"Wilder\u2010Smith","sequence":"additional","affiliation":[{"name":"Division of Neurology National University Hospital Level 10 Tower Block, University Medicine Cluster, 1E Kent Ridge Road 119228 Singapore"},{"name":"Neurology, Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.97"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150605"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10181"},{"key":"e_1_2_5_5_1","first-page":"1398","article-title":"Small fiber neuropathies","volume":"20","author":"Gibbons CH","year":"2014","journal-title":"Continuum"},{"key":"e_1_2_5_6_1","first-page":"621\u2013633","article-title":"Painful small\u2010fiber neuropathies","volume":"81","author":"Sommer C","year":"2006","journal-title":"Handb Clin Neurol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-012-0280-9"},{"key":"e_1_2_5_8_1","first-page":"82","article-title":"Pathology and functional diagnosis of small\u2010fiber painful neuropathy","volume":"19","author":"Hsieh ST","year":"2010","journal-title":"Acta Neurol Taiwan"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32835804c5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2013-000758"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-011-0181-7"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7379.41"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a8236e"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00075307"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22255"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23757"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.99"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00252.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.128801"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1532-0"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01568.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn093"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1303"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216080109"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu079"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03023.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00271.x"},{"key":"e_1_2_5_28_1","first-page":"333\u2013338","article-title":"Stancanelli A, et al. 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