{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:51:36Z","timestamp":1791179496106,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:italic>\n : The sarcoglycanopathies are a heterogeneous group of autosomal recessive limb\u2010girdle muscular dystrophies that cause varying degrees of progressive proximal muscle weakness.\n Methods<\/jats:italic>\n : We describe the case of a Caucasian girl who presented with exercise intolerance, myalgia, and dark urine. Onset of symptoms was at age 4, and she had myalgia with physical activity throughout childhood. Creatine kinase levels were as high as 18,000.\n Results<\/jats:italic>\n : Immunostaining of a muscle biopsy showed mildly diminished alpha sarcoglycan staining, and\n SGCA<\/jats:italic>\n gene sequencing revealed n.C229T; p.Arg77Cys (R77C) and n.C850T; p.Arg284Cys (R284C), which is associated with alpha sarcoglycanopathy.\n Conclusions<\/jats:italic>\n : This patient presented with exercise intolerance, myoglobinuria, and almost normal muscle strength into adolescence, which is uncommon in sarcoglycanopathies. This uncommon presentation should be kept in mind, so that early recognition and intervention may prevent future comorbidities and help preserve the quality of life.\n Muscle Nerve<\/jats:italic>\n 54<\/jats:bold>\n : 161\u2013164, 2016\n <\/jats:p>","DOI":"10.1002\/mus.25109","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T12:16:35Z","timestamp":1458389795000},"page":"161-164","source":"Crossref","is-referenced-by-count":8,"title":["Young girl presenting with exercise\u2010induced myoglobinuria"],"prefix":"10.1002","volume":"54","author":[{"given":"Balaji","family":"Krishnaiah","sequence":"first","affiliation":[{"name":"Department of Neurology Penn State University 30 Hope Drive, EC 037 Hershey Pennsylvania 17033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Jheesoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Penn State University Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew Paul","family":"Wicklund","sequence":"additional","affiliation":[{"name":"Department of Neurology Penn State University 30 Hope Drive, EC 037 Hershey Pennsylvania 17033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divpreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Neurology Penn State University 30 Hope Drive, EC 037 Hershey Pennsylvania 17033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-045031-5.00003-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(00)00207-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(96)00389-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096-195"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.14.2801"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.5.967"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.6.1399"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200110000-00004"},{"key":"e_1_2_7_10_1","first-page":"446","article-title":"Sarcoglycanopathies: a clinicopathological study of 13 cases [corrected]","volume":"52","author":"Sharma MC","year":"2004","journal-title":"Neurol India"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-266"}],"container-title":["Muscle & Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.25109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.25109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.25109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.25109","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.25109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:02:03Z","timestamp":1791176523000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.25109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,28]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/mus.25109"],"URL":"https:\/\/doi.org\/10.1002\/mus.25109","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,28]]}}}