{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:50:58Z","timestamp":1784569858107,"version":"3.55.0"},"reference-count":79,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: There is evidence that supports a role for Vitamin D (Vit. D) in muscle. The exact mechanism by which Vit. D deficiency impairs muscle strength and function is not clear. <jats:italic>Methods<\/jats:italic>: Three\u2010week\u2010old mice were fed diets with varied combinations of Vit. D and Ca<jats:sup>2+<\/jats:sup> deficiency. Behavioral testing, genomic and protein analysis, and muscle histology were performed with a focus on neuromuscular junction (NMJ) \u2010related genes. <jats:italic>Results<\/jats:italic>: Vit. D and Ca<jats:sup>2+<\/jats:sup> deficient mice performed more poorly on given behavioral tasks than animals with Vit. D deficiency alone. Genomic and protein analysis of the soleus and tibialis anterior muscles revealed changes in several Vit. D metabolic, NMJ\u2010related, and protein chaperoning and refolding genes. <jats:italic>Conclusions<\/jats:italic>: These data suggest that detrimental effects of a Vit. D deficient or a Vit. D and Ca<jats:sup>2+<\/jats:sup> deficient diet may be a result of differential alterations in the structure and function of the NMJ and a lack of a sustained stress response in muscles. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>54<\/jats:bold>: 1120\u20131132, 2016<\/jats:p>","DOI":"10.1002\/mus.25146","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T13:38:56Z","timestamp":1460554736000},"page":"1120-1132","source":"Crossref","is-referenced-by-count":26,"title":["Vitamin D and\/or calcium deficient diets may differentially affect muscle fiber neuromuscular junction innervation"],"prefix":"10.1002","volume":"54","author":[{"given":"David J.","family":"Gifondorwa","sequence":"first","affiliation":[{"name":"Eli Lilly and Company Research Laboratories Laboratory for Experimental Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyran 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