{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:08:53Z","timestamp":1789783733703,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30972859"],"award-info":[{"award-number":["30972859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: The aim of this study was to study the effects of sepsis on diaphragm relaxation properties and the associated expression of sarco\u2010endoplasmic reticulum Ca<jats:sup>2+<\/jats:sup>\u2010ATPase genes <jats:italic>SERCA1<\/jats:italic> and <jats:italic>SERCA2<\/jats:italic>. <jats:italic>Methods<\/jats:italic>: Rats were randomized to undergo either sham surgery or cecal ligation and puncture (CLP). Diaphragm isometric relaxation parameters were measured after 24 h. The mRNA expression and protein content of SERCA1 and SERCA2 in diaphragm muscles were determined. <jats:italic>Results<\/jats:italic>: Both diaphragm maximal twitch and tetanus relaxation rates were reduced. Twitch half\u2010relaxation time was prolonged after normalization to half of peak twitch tension. The mRNA expression and protein content of SERCA1 and SERCA2 were decreased. <jats:italic>Conclusions<\/jats:italic>: Slowed relaxation of the diaphragm in septic rats was associated with reduced expression of <jats:italic>SERCA1<\/jats:italic> and <jats:italic>SERCA2<\/jats:italic>. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>54<\/jats:bold>: 1108\u20131113, 2016<\/jats:p>","DOI":"10.1002\/mus.25150","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T23:11:08Z","timestamp":1461366668000},"page":"1108-1113","source":"Crossref","is-referenced-by-count":12,"title":["Slowed relaxation of diaphragm in septic rats is associated with reduced expression of sarco\u2010endoplasmic reticulum CA<sup>2+<\/sup>\u2010ATPase genes <i>SERCA1<\/i> and <i>SERCA2<\/i>"],"prefix":"10.1002","volume":"54","author":[{"given":"Jin","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, First People's Hospital, School of Medicine Shanghai Jiaotong University 100 Hai Ning Road Shanghai 20080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian You","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, First People's Hospital, School of Medicine Shanghai Jiaotong University 100 Hai Ning Road Shanghai 20080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, First People's Hospital, School of Medicine Shanghai Jiaotong University 100 Hai Ning Road Shanghai 20080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Tong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, First People's Hospital, School of Medicine Shanghai Jiaotong University 100 Hai Ning Road Shanghai 20080 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