{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:11:51Z","timestamp":1791594711586,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,15]],"date-time":"2016-10-15T00:00:00Z","timestamp":1476489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Jeju National University Hospital Research Fund in 2013"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> Myasthenia gravis (MG) is a B\u2010cell\u2013mediated autoimmune disease. B\u2010cell\u2013activating factor (BAFF) is a major factor in B\u2010cell development and activation. In this study we investigated serum BAFF levels in MG patients. <jats:italic>Methods:<\/jats:italic> We compared the serum BAFF levels of 20 MG patients with gender\u2010matched healthy controls. We assayed serum concentrations of BAFF and anti\u2010acetylcholine receptor antibody (AChR) titers. <jats:italic>Results:<\/jats:italic> Serum BAFF levels of MG patients with AChR antibodies were significantly higher than those of healthy controls. A significant positive correlation was observed between serum BAFF levels and anti\u2010AChR antibody titers. BAFF values did not correlate with disease severity. <jats:italic>Conclusions:<\/jats:italic> BAFF may play a major role in the pathogenesis of MG, and it may provide a potential target for therapy in patients with MG. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>54<\/jats:bold>: 1030\u20131033, 2016<\/jats:p>","DOI":"10.1002\/mus.25162","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:41:32Z","timestamp":1461804092000},"page":"1030-1033","source":"Crossref","is-referenced-by-count":34,"title":["B\u2010cell\u2013activating factor is elevated in serum of patients with myasthenia gravis"],"prefix":"10.1002","volume":"54","author":[{"given":"Sa\u2010Yoon","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Neurology Jeju National University School of Medicine 1 Ara 1\u2010dong, Jeju\u2010si Jeju 690\u2010756 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul\u2010Hoo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology Jeju National University School of Medicine 1 Ara 1\u2010dong, Jeju\u2010si Jeju 690\u2010756 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun\u2010Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology Jeju National University School of Medicine Jeju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5425.260"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.198"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.11.1697"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2006.04.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.05.010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.10.1358"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6092-z"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06842.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24628"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2005.08.004"},{"key":"e_1_2_6_12_1","first-page":"1256","article-title":"Concentrations of BAFF correlate with autoantibody levels, clinical disease activity, and response to treatment in early rheumatoid arthritis","volume":"35","author":"Bosello S","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.2.168"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c919ee"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.12.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.1935"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2007.01921.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.05.023"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.11.009"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06431.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.807"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh043"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.25162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.25162","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.25162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T11:26:50Z","timestamp":1696505210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.25162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,15]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/mus.25162"],"URL":"https:\/\/doi.org\/10.1002\/mus.25162","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,15]]}}}