{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:49:15Z","timestamp":1782992955192,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Single fiber electromyography (SFEMG) is the most sensitive diagnostic tool for diagnosis of myasthenia gravis (MG). Its prognostic value is not known. <jats:italic>Methods<\/jats:italic>: We retrospectively analyzed the clinical course of 232 MG patients who presented with only mild symptoms and had SFEMG of the orbicularis oculi muscle. We correlated their SFEMG results with the severity of their later clinical course. <jats:italic>Results<\/jats:italic>: During the observation period 39 patients (17%) developed severe disease exacerbations, and 193 (83%) remained stable. Patients with severe disease exacerbation had a significantly higher mean jitter value (<jats:italic>P<\/jats:italic> &lt; 0.0001), a greater percentage of fibers with increased jitter (<jats:italic>P<\/jats:italic> &lt; 0.0001), and\/or impulse blocking (<jats:italic>P<\/jats:italic> &lt; 0.0001) on SFEMG. <jats:italic>Conclusions<\/jats:italic>: The extent of the SFEMG abnormalities in this study correlated with the later clinical course of MG. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>54<\/jats:bold>: 1034\u20131040, 2016<\/jats:p>","DOI":"10.1002\/mus.25174","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T16:07:02Z","timestamp":1462378022000},"page":"1034-1040","source":"Crossref","is-referenced-by-count":28,"title":["Single fiber EMG as a prognostic tool in myasthenia gravis"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5895-3136","authenticated-orcid":false,"given":"Mateja","family":"Baruca","sequence":"first","affiliation":[{"name":"University Medical Centre Ljubljana, Department of Neurology Zalo\u0161ka cesta 2,1000 Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Leonardis","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana, Institute of Clinical Neurophysiology Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Podnar","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana, Institute of Clinical Neurophysiology Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Hojs\u2010Fabjan","sequence":"additional","affiliation":[{"name":"University Medical Centre Maribor, Department of Neurology Maribor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Grad","sequence":"additional","affiliation":[{"name":"General Hospital of Isola Isola Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale\u0161","family":"Jerin","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana, Clinical institute of Clinical Chemistry and biochemistry Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rok","family":"Blagus","sequence":"additional","affiliation":[{"name":"Institute for Biostatistics and Medical Informatics University of Ljubljana, Faculty of Medicine Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u0161a","family":"\u0160ega\u2010Jazbec","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana, Department of Neurology Zalo\u0161ka cesta 2,1000 Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.072355"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03017.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20435"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00307-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.05.006"},{"key":"e_1_2_7_7_1","first-page":"254","article-title":"Serial single\u2010fiber EMG studies in myasthenic patients treated with corticosteroids and plasma exchange therapy","volume":"4","author":"Howard JF","year":"1981","journal-title":"Muscle Nerve"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1212\/WNL.31.4_Part_2.386","article-title":"Myasthenia gravis: relation between jitter in single\u2010fiber EMG and antibody to acetylcholine receptor","volume":"31","author":"Konishi T","year":"1981","journal-title":"Neurology"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10141"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(97)02245-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200309000-00011"},{"key":"e_1_2_7_12_1","unstructured":"R: A language and environment for statistical computing.R Foundation for Statistical Computing Vienna Austria. 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