{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:13:29Z","timestamp":1789179209050,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: The diagnosis of myasthenia gravis in very young infants is a challenging one. In young infants, stimulated single\u2010fiber electromyography (StimSFEMG) is the most appropriate technique, but it has serious limitations due to the absence of reference values in this subpopulation. Here we present our efforts to derive a reference range of jitter in a patient cohort of infants &lt;3 years of age using the extrapolated norms, or e\u2010norms, technique. <jats:italic>Methods<\/jats:italic>: The e\u2010norms method was used to calculate jitter mean consecutive difference (MCD) descriptive statistics for children &lt;3 years of age. <jats:italic>Results<\/jats:italic>: The e\u2010norms derived jitter upper MCD limit was 45 \u03bcs in children &lt;1 year, 33 \u03bcs in those &lt;2 years, and 26 in those &lt;3 years of age. <jats:italic>Conclusion<\/jats:italic>: In the absence of jitter reference values for the very young, the e\u2010norms method can be used as an alternative to derive these values from laboratory cohorts. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>55<\/jats:bold>: 51\u201354, 2017<\/jats:p>","DOI":"10.1002\/mus.25191","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T08:43:40Z","timestamp":1463474620000},"page":"51-54","source":"Crossref","is-referenced-by-count":29,"title":["Determining jitter values in the very young by use of the e\u2010norms methodology"],"prefix":"10.1002","volume":"55","author":[{"given":"Matthew C.","family":"Pitt","sequence":"first","affiliation":[{"name":"Department of Clinical Neurophysiology Great Ormond Street Hospital for Children NHS Foundation Trust London WC1N 3JH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe F.","family":"Jabre","sequence":"additional","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(01)00336-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2011.08.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.10.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70201-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.06.026"},{"key":"e_1_2_6_7_1","volume-title":"Single fiber EMG","author":"St\u00e5lberg EV","year":"2010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880120802"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.02038.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.05.018"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200005)23:5<715::AID-MUS8>3.0.CO;2-V"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23929"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000161"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2010.07.012"},{"key":"e_1_2_6_15_1","unstructured":"JabreJF.E\u2010norms: a novel technique to extrapolate normal values from a patient population data. In: Proceedings of the 30th International Congress of Clinical Neurophysiology Berlin Germany. Amsterdam: Elsevier;2014. p274."},{"key":"e_1_2_6_16_1","first-page":"S30","article-title":"Confirming normal jitter limits using the extrapolated normal method","volume":"52","author":"Nandedkar SD","year":"2015","journal-title":"Muscle Nerve"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21424"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.25191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.25191","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.25191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.25191","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.25191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T01:09:13Z","timestamp":1694135353000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.25191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,18]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/mus.25191"],"URL":"https:\/\/doi.org\/10.1002\/mus.25191","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,18]]}}}