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Patients suffer progressive muscle loss, and cardiomyopathy is an important determinant of morbidity. P2 purinergic receptors participate in the increased calcium levels in dystrophic skeletal muscles. <jats:italic>Methods:<\/jats:italic> In this study, we evaluated whether P2 receptors are involved in cardiomyopathy in <jats:italic>mdx<\/jats:italic> mice at later stages of the disease. <jats:italic>Results<\/jats:italic>: Western blotting revealed that P2Y<jats:sub>2<\/jats:sub> receptor levels were upregulated (54%) in dystrophic heart compared with a normal heart. Suramin reduced the levels of P2Y<jats:sub>2<\/jats:sub> to almost normal values. Suramin also decreased heart necrosis (reduced CK\u2010MB) and the expression of the stretch\u2010activated calcium channel TRPC1. <jats:italic>Conclusions<\/jats:italic>: This study suggests that P2Y<jats:sub>2<\/jats:sub> may participate in cardiomyopathy in <jats:italic>mdx<\/jats:italic> mice. P2\u2010selective drugs with specific actions in the dystrophic heart may ameliorate cardiomyopathy in dystrophinopathies. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>55<\/jats:bold>: 116\u2013121, 2017<\/jats:p>","DOI":"10.1002\/mus.25199","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T03:11:34Z","timestamp":1464145894000},"page":"116-121","source":"Crossref","is-referenced-by-count":11,"title":["P2Y<sub>2<\/sub> purinergic receptors are highly expressed in cardiac and diaphragm muscles of <i>mdx<\/i> mice, and their expression is decreased by suramin"],"prefix":"10.1002","volume":"55","author":[{"given":"Drielen","family":"De Oliveira Moreira","sequence":"first","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional, Instituto de Biologia Universidade Estadual de Campinas (UNICAMP) Campinas S\u00e3o Paulo 13083\u2010970 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto","family":"Santo 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