{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:25Z","timestamp":1786978225698,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T00:00:00Z","timestamp":1478217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      We quantified intraneural blood flow (INBF) using perfusion measurement software (PixelFlux), and compared it with the qualitative method of counting blood vessels (vessel score) in a cohort of carpal tunnel syndrome (CTS) patients.\n                      <jats:italic>Methods:<\/jats:italic>\n                      Forty\u2010seven patients (67 wrists) with a clinical and electrophysiological diagnosis of CTS, and 20 healthy controls (40 wrists) were enrolled. Median nerve ultrasound (US) was performed at the carpal tunnel inlet to measure the cross\u2010sectional area (CSA) and vessel score. Power Doppler sonograms from nerves with detectable INBF were processed with PixelFlux to obtain the maximum perfusion intensity (MPI).\n                      <jats:italic>Results:<\/jats:italic>\n                      Forty\u2010nine percent of CTS patients had detectable INBF compared with none in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). MPI correlated significantly with vessel score (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.945,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001), CSA (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.613,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and electrophysiological severity (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.440,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). MPI had higher intra\u2010 or interobserver reliability compared with vessel score (0.95 vs. 0.47).\n                      <jats:italic>Conclusion:<\/jats:italic>\n                      MPI is a better method for quantification of INBF.\n                      <jats:italic>Muscle Nerve<\/jats:italic>\n                      , 2016\n                      <jats:italic>Muscle Nerve<\/jats:italic>\n                      <jats:bold>55<\/jats:bold>\n                      : 77\u201383, 2017\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.25200","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T08:04:06Z","timestamp":1464249846000},"page":"77-83","source":"Crossref","is-referenced-by-count":31,"title":["Utility of maximum perfusion intensity as an ultrasonographic marker of intraneural blood flow"],"prefix":"10.1002","volume":"55","author":[{"given":"Adeniyi A.","family":"Borire","sequence":"first","affiliation":[{"name":"Prince of Wales Clinical School University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo H.","family":"Visser","sequence":"additional","affiliation":[{"name":"St. Elisabeth Ziekenhuis Tilburg The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Padua","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Neurosciences, and Orthopedics Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"},{"name":"Don Gnocchi Foundation Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Colebatch","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School University of New South Wales Sydney New South Wales Australia"},{"name":"Institute of Neurological Sciences, Prince of Wales Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Huynh","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, Prince of Wales Hospital Sydney New South Wales Australia"},{"name":"Brain and Mind Centre University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1784-8238","authenticated-orcid":false,"given":"Neil G.","family":"Simon","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre University of Sydney Sydney New South Wales Australia"},{"name":"St. Vincent's Clinical School University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Kiernan","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun V.","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School University of New South Wales Sydney New South Wales Australia"},{"name":"Institute of Neurological Sciences, Prince of Wales Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10227"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.05.023"},{"key":"e_1_2_6_4_1","first-page":"287","article-title":"et al","volume":"46","author":"Cartwright MS","year":"2012","journal-title":"Evidence\u2010based guideline: neuromuscular ultrasound for the diagnosis of carpal tunnel syndrome. 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Ann Rheum Dis"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23505"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12182"},{"key":"e_1_2_6_12_1","first-page":"498","article-title":"et al","volume":"3","author":"Jain S","year":"2009","journal-title":"High resolution sonography: a new technique to detect nerve damage in leprosy. 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