{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T13:57:44Z","timestamp":1761400664638},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: The aim of this study was to estimate jitter parameters in the orbicularis oculi muscle using a concentric needle electrode (CNE) in patients with myasthenia gravis (MG) and to determine its diagnostic accuracy for jitter analysis (CNEMG\u2010jitter). <jats:italic>Methods<\/jats:italic>: CNEMG\u2010jitter was performed in 20 healthy subjects and 33\u2009MG patients using the voluntary contraction technique. Receiver operating characteristic (ROC) curves were constructed to determine cut\u2010off points with the best sensitivity\/specificity combination for jitter analysis. <jats:italic>Results<\/jats:italic>: CNEMG\u2010jitter yielded high positivity rates for ocular MG (92.3%) and generalized MG (100%). The ROC curve cut\u2010off point that provided the highest sensitivity without false positives was 24.7 \u03bcs for mean jitter and 33.1 \u03bcs for the 18th highest value. Sensitivity was 93.9% for both parameters. Diagnostic accuracy of CNEMG\u2010jitter was\u2009&gt;\u200996%. <jats:italic>Conclusions<\/jats:italic>: CNEMG\u2010jitter yielded high sensitivity and specificity rates. Our reference values were lower than previously published values, possibly due to less technical variation between the different recordings. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>55<\/jats:bold>: 190\u2013194, 2017<\/jats:p>","DOI":"10.1002\/mus.25229","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T17:17:15Z","timestamp":1467047835000},"page":"190-194","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic accuracy of concentric needle jitter in myasthenia: Prospective study"],"prefix":"10.1002","volume":"55","author":[{"given":"Flavia","family":"C.N. Machado","sequence":"first","affiliation":[{"name":"Department of Neurology Medical School, Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Fleury Medicina e Sa\u00fade S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JO\u00c3O","family":"A. Kouyoumdjian","sequence":"additional","affiliation":[{"name":"Neuromuscular Investigation Laboratory Faculdade Medicina S\u00e3o Jos\u00e9 do Rio Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"E. Marchiori","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical School, Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20568"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200005)23:5<715::AID-MUS8>3.0.CO;2-V"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20435"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21151"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.02.026"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23709"},{"key":"e_1_2_6_8_1","first-page":"351","article-title":"et al","volume":"53","author":"St\u02dalberg E","year":"2016","journal-title":"Reference values for jitter recorded by concentric needle electrodes in healthy controls: a multicenter study. 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Clin Neurophysiol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.09.028"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10426"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.814"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199609)19:9<1069::AID-MUS1>3.0.CO;2-Y"},{"key":"e_1_2_6_16_1","first-page":"16","article-title":"et al","volume":"55","author":"Jaretzki A","year":"2000","journal-title":"Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. 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