{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T06:54:35Z","timestamp":1770447275898,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T00:00:00Z","timestamp":1486944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Voltage\u2010gated Kv1 potassium channel complex (VGKC) autoantibodies subtyped for leucine\u2010rich glioma\u2010inactivated 1 (LGI1), contactin\u2010associated\u2010proteinlike 2 (CASPR2), and Kv IgGs have a spectrum of neurological presentations. Painful polyneuropathy is seen in some patients, but nerve pathology descriptions are lacking. <jats:italic>Methods<\/jats:italic>: Clinicopathologic features were studied in subtyped VGKC\u2010autoantibody\u2010seropositive patients who had undergone nerve biopsies. <jats:italic>Results<\/jats:italic>: Five patients were identified, 1 LGI1 IgG positive and 1 CASPR2 IgG positive, but all negative for Kv1.1\u2010, 1.2\u2010, 1.6\u2010subtyped IgG autoantibodies. Median symptom duration was 17 months. Pain was the predominant symptom; 3 had mild sensory loss and\/or weakness. Histopathological abnormalities were limited to axonal loss in 3. None had mononuclear cellular infiltrates. Electron micrographs revealed no interstitial abnormalities. Three patients reported marked improvement in pain with immunotherapy. <jats:italic>Conclusions<\/jats:italic>: The nerve biopsy histopathology of patients subtyped for LGI1 and CASPR2 IgGs within the VGKC\u2010complex spectrum disorders shows either normal density or axonal fiber loss without inflammatory infiltrates. A reversible neural hyperexcitable mechanism is considered to be the cause of this painful polyneuropathy. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>55<\/jats:bold>: 520\u2013525, 2017<\/jats:p>","DOI":"10.1002\/mus.25371","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T08:53:19Z","timestamp":1470905599000},"page":"520-525","source":"Crossref","is-referenced-by-count":22,"title":["Clinical\u2010pathologic correlations in voltage\u2010gated Kv1 potassium channel complex\u2010subtyped autoimmune painful polyneuropathy"],"prefix":"10.1002","volume":"55","author":[{"given":"Rajat","family":"Lahoria","sequence":"first","affiliation":[{"name":"Peripheral Neuropathy Research Laboratory, Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean J.","family":"Pittock","sequence":"additional","affiliation":[{"name":"Neuroimmunology Laboratory, Mayo Clinic 200 First Street SW Rochester Minnesota 55905 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avi","family":"Gadoth","sequence":"additional","affiliation":[{"name":"Neuroimmunology Laboratory, Mayo Clinic 200 First Street SW Rochester Minnesota 55905 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janean K.","family":"Engelstad","sequence":"additional","affiliation":[{"name":"Peripheral Neuropathy Research Laboratory, Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanda A.","family":"Lennon","sequence":"additional","affiliation":[{"name":"Neuroimmunology Laboratory, Mayo Clinic 200 First Street SW Rochester Minnesota 55905 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Klein","sequence":"additional","affiliation":[{"name":"Peripheral Neuropathy Research Laboratory, Mayo Clinic Rochester Minnesota USA"},{"name":"Neuroimmunology Laboratory, Mayo Clinic 200 First Street SW Rochester Minnesota 55905 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.3.771"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410215"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.592"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182698cab"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827040a3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.130039"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh077"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq213"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22297"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2019"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200305078"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.03.008"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380505"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.11.2057"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10148"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws082"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080608"},{"key":"e_1_2_6_19_1","first-page":"75","volume-title":"Disorders of the motor unit","author":"Dyck PJ","year":"1982"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002037"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22496"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns5.12056"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4661-09.2010"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22485"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002637"}],"container-title":["Muscle &amp; 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