{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:31:24Z","timestamp":1790742684753,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There is a growing need for a robust clinical measure to assess upper limb motor function in spinal muscular atrophy (SMA), as the available scales lack sensitivity at the extremes of the clinical spectrum. We report the development of the Revised Upper Limb Module (RULM), an assessment specifically designed for upper limb function in SMA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An international panel with specific neuromuscular expertise performed a thorough review of scales currently available to assess upper limb function in SMA. This review facilitated a revision of the existing upper limb function scales to make a more robust clinical scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multiple revisions of the scale included statistical analysis and captured clinically relevant changes to fulfill requirements by regulators and advocacy groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The resulting RULM scale shows good reliability and validity, making it a suitable tool to assess upper extremity function in the SMA population for multi\u2010center clinical research. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>55<\/jats:bold>: 869\u2013874, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25430","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T15:36:43Z","timestamp":1476286603000},"page":"869-874","source":"Crossref","is-referenced-by-count":297,"title":["Revised upper limb module for spinal muscular atrophy: Development of a new module"],"prefix":"10.1002","volume":"55","author":[{"given":"Elena S.","family":"Mazzone","sequence":"first","affiliation":[{"name":"Department of Paediatric Neurology Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mayhew","sequence":"additional","affiliation":[{"name":"Institute of Genetic Medicine Newcastle University Newcastle United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Montes","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Centre UCL Institute of Child Health &amp; Great Ormond Street Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Fanelli","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally Dunaway","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Salazar","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"De Sanctis","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Pasternak","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Glanzman","sequence":"additional","affiliation":[{"name":"Division of Neurology, Children's Hospital of Philadelphia and Departments of Neurology and Pediatrics Perelman School of Medicine at the University of Pennsylvania Philadelphia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Coratti","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Civitello","sequence":"additional","affiliation":[{"name":"Division of Neurology Nemours Children's Hospital Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Forcina","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Gee","sequence":"additional","affiliation":[{"name":"Department of Neurology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of Neurology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Pane","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariacristina","family":"Scoto","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Centre UCL Institute of Child Health &amp; 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