{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T22:32:21Z","timestamp":1766788341621},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hodgkin lymphoma (HL) is a common lymphoid malignancy rarely associated with Guillain\u2013Barr\u00e9 syndrome (GBS). In most cases, GBS does not precede HL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe a patient with acute inflammatory demyelinating polyneuropathy who fulfilled criteria for GBS that heralded undiagnosed HL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cerebrospinal fluid (CSF) studies revealed albuminocytologic dissociation with significant protein elevation (250\u2009mg\/dl). The patient worsened during intravenous immunoglobulin (IVIg) therapy. Constitutional symptoms with elevated inflammatory markers prompted further investigation, and imaging revealed an anterior mediastinal mass confirmed on biopsy to be HL. Chemotherapy yielded early clinical improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GBS preceding HL is rare, and this case highlights the importance of considering HL in the setting of GBS. Marked elevations in CSF protein, ongoing deterioration despite administration of IVIg, and constitutional symptoms with elevated inflammatory markers may be clues to possible HL\u2010induced GBS. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>55<\/jats:bold>: 601\u2013604, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25439","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T23:22:38Z","timestamp":1476832958000},"page":"601-604","source":"Crossref","is-referenced-by-count":8,"title":["Neurological Nuance: Hodgkin lymphoma presenting with Guillain\u2013Barr\u00c9 syndrome"],"prefix":"10.1002","volume":"55","author":[{"given":"Dustin","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Medicine (Neurology) University of Alberta 7\u2010132A Clinical Sciences Building, 11350\u201083 Avenue Edmonton Alberta T6G 2G3 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grayson","family":"Beecher","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology) University of Alberta 7\u2010132A Clinical Sciences Building, 11350\u201083 Avenue Edmonton Alberta T6G 2G3 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor A.","family":"Steve","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology) University of Alberta 7\u2010132A Clinical Sciences Building, 11350\u201083 Avenue Edmonton Alberta T6G 2G3 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho","family":"Jen","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Diagnostic Imaging University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Camicioli","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology) University of Alberta 7\u2010132A Clinical Sciences Building, 11350\u201083 Avenue Edmonton Alberta T6G 2G3 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas W.","family":"Zochodne","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology) University of Alberta 7\u2010132A Clinical Sciences Building, 11350\u201083 Avenue Edmonton Alberta T6G 2G3 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2009.1.491"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820d62eb"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1177\/014107689408700915","article-title":"Effects of lymphoma on the peripheral nervous system","volume":"87","author":"Hughes RA","year":"1994","journal-title":"J R Soc Med"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410010107"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(80)80003-7"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.8.7.575"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.125930"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199009273231308"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/milmed\/148.6.512","article-title":"Hodgkin's disease in association with Guillain\u2010Barr\u00e9\u2010Strohl syndrome: case report","volume":"148","author":"Amundson DE","year":"1983","journal-title":"Milit Med"},{"key":"e_1_2_5_11_1","first-page":"415","article-title":"Guillain\u2010Barr\u00e9 syndrome in a patient with Hodgkin's disease","volume":"45","author":"Cuttner J","year":"1978","journal-title":"Mt Sinai J Med NY"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70215-1"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.999"},{"key":"e_1_2_5_14_1","first-page":"586","article-title":"Double\u2010blind trial of intravenous methylprednisolone in Guillain\u2010Barr\u00e9 syndrome","volume":"341","year":"1993","journal-title":"Lancet"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.74.4.281"},{"key":"e_1_2_5_16_1","first-page":"57","volume-title":"Guillain\u2010Barr\u00e9 syndrome","author":"Ropper AH","year":"1991"},{"key":"e_1_2_5_17_1","first-page":"138","article-title":"Comparison of electrophysiological findings in axonal and demyelinating Guillain\u2010Barr\u00e9 syndrome","volume":"13","author":"Yadegari S","year":"2014","journal-title":"Iran J Neurol"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.4.841"}],"container-title":["Muscle &amp; 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