{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:36:55Z","timestamp":1758127015113},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation of South Africa","award":["81837","81837"],"award-info":[{"award-number":["81837","81837"]}]},{"name":"Fondo de Investigaciones Sanitarias","award":["PI15\/00431","PI14\/00903","grant PI12\/00914","PI13\/01258"],"award-info":[{"award-number":["PI15\/00431","PI14\/00903","grant PI12\/00914","PI13\/01258"]}]},{"name":"Regional Development Fund"},{"name":"Regional Development Fund"},{"name":"Tim and Marylin Noakes Postdoctoral fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>McArdle disease is a metabolic myopathy that presents with exercise intolerance and episodic rhabdomyolysis. Excessive muscle recruitment has also been shown to be present during strenuous exercise, suggesting decreased power output. These findings could potentially be explained by either impaired contractility, decreased fiber size, or altered fiber type proportion. However, there is a paucity of data on the morphological features seen on muscle histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined muscle biopsies of patients with McArdle disease from a Spanish cohort and compared the findings with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found no significant difference in the fiber type proportion or mean fiber size between McArdle patients and controls in the biceps brachii or vastus lateralis muscles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No alterations in muscle fiber type proportion or size were found on muscle histology of patients with McArdle disease. Future research should focus on assessment of muscle fiber contractility to investigate the functional impairment. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>55<\/jats:bold>: 916\u2013918, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25472","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T15:30:13Z","timestamp":1479310213000},"page":"916-918","source":"Crossref","is-referenced-by-count":4,"title":["Muscle fiber type proportion and size is not altered in mcardle disease"],"prefix":"10.1002","volume":"55","author":[{"given":"Franclo","family":"Henning","sequence":"first","affiliation":[{"name":"Division of Exercise Science and Sports Medicine, Department of Human Biology University of Cape Town PO Box 115 Newlands 7725 South Africa"},{"name":"Division of Neurology, Department of Medicine, Faculty of Medicine and Health Sciences Stellenbosch University  South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol Anne","family":"Cunninghame","sequence":"additional","affiliation":[{"name":"Division of Exercise Science and Sports Medicine, Department of Human Biology University of Cape Town PO Box 115 Newlands 7725 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Mitochondrial and Neuromuscular Diseases Laboratory, Hospital 12 de Octubre Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n, Hospital 12 de Octubre (i+12) Madrid Spain"},{"name":"Spanish Center for Biomedical Research in Rare Diseases (CIBERER) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Rubio","sequence":"additional","affiliation":[{"name":"Mitochondrial and Neuromuscular Diseases Laboratory, Hospital 12 de Octubre Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n, Hospital 12 de Octubre (i+12) Madrid Spain"},{"name":"Spanish Center for Biomedical Research in Rare Diseases (CIBERER) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Arenas","sequence":"additional","affiliation":[{"name":"Mitochondrial and Neuromuscular Diseases Laboratory, Hospital 12 de Octubre Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n, Hospital 12 de Octubre (i+12) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Lucia","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n, Hospital 12 de Octubre (i+12) Madrid Spain"},{"name":"European University of Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelio","family":"Hern\u00e1Ndez\u2010La\u00edn","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n, Hospital 12 de Octubre (i+12) Madrid Spain"},{"name":"Neuropathology Department, Hospital 12 de Octubre Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tertius Abraham","family":"Kohn","sequence":"additional","affiliation":[{"name":"Division of Exercise Science and Sports Medicine, Department of Human Biology University of Cape Town PO Box 115 Newlands 7725 South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301593"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22806"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21351"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1585-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.078485"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.20149548"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.2.581"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1990.tb08974.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1972.33.3.312"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1977.tb05956.x"}],"container-title":["Muscle &amp; 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