{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:32Z","timestamp":1786978232226,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006010","name":"Bayer Schering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004329","name":"Genzyme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006259","name":"Teva Pharmaceutical Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cramp\u2010fasciculation syndrome is a peripheral nerve hyperexcitability disorder, which could be caused by inflammatory neuropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>We describe a 51\u2010year\u2010old woman who presented with a 4\u2010 to 5\u2010year history of fasciculations and painful cramping of the right thenar eminence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Electrophysiological studies showed motor conduction block in the right median nerve between the axilla and the elbow with fasciculation potentials and cramp discharges on electromyography in the right abductor pollicis brevis muscle. High titers of serum anti\u2010GM1 immunoglobulin M antibodies were detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Monofocal motor neuropathy of the right median nerve was diagnosed. Intravenous immunoglobulin treatment led to significant improvement of symptoms and signs. Although fasciculations and cramps have been reported in multifocal motor neuropathy and are considered supporting criteria for the diagnosis, the occurrence of cramp\u2010fasciculation syndrome as the presenting feature and predominant manifestation in monofocal motor neuropathy, a variant of multifocal motor neuropathy, is unique.\n                      <jats:italic>Muscle Nerve<\/jats:italic>\n                      <jats:bold>56<\/jats:bold>\n                      : 828\u2013832, 2017\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.25528","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T09:50:38Z","timestamp":1482573038000},"page":"828-832","source":"Crossref","is-referenced-by-count":4,"title":["Cramp\u2010fasciculation syndrome associated with monofocal motor neuropathy"],"prefix":"10.1002","volume":"56","author":[{"given":"Nicolas J.","family":"Dubuisson","sequence":"first","affiliation":[{"name":"Neuromuscular Reference Center Cliniques universitaires Saint\u2010Luc Avenue Hippocrate 10\/13.11 1200 Brussels Belgium"},{"name":"Department of Neurology University Hospitals St\u2010Luc, University of Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Van Pesch","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospitals St\u2010Luc, University of Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Y.K.","family":"Van Den Bergh","sequence":"additional","affiliation":[{"name":"Neuromuscular Reference Center Cliniques universitaires Saint\u2010Luc Avenue Hippocrate 10\/13.11 1200 Brussels Belgium"},{"name":"Department of Neurology University Hospitals St\u2010Luc, University of Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.7.1021"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00290.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200010)23:10<1610::AID-MUS22>3.0.CO;2-D"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10088"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.04.010"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21005"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181ff94c2"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000275523.95103.36"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90073-X"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.2.453"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380505"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410215"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182061b1e"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23935"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000116045"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(87)90006-X"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199704)20:4<479::AID-MUS11>3.0.CO;2-U"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318227b202"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199602)19:2<210::AID-MUS13>3.0.CO;2-Y"},{"key":"e_1_2_5_21_1","first-page":"206","article-title":"Isaacs syndrome associated with CIDP and pregnancy","volume":"14","author":"Basiri K","year":"2011","journal-title":"Arch Iran Med"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199904)22:4<532::AID-MUS17>3.0.CO;2-X"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.09.013"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.09.012"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4401-06.2007"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq119"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000119"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24680"},{"issue":"3","key":"e_1_2_5_29_1","first-page":"664","volume":"125","author":"Kiernan MC","year":"2002","journal-title":"Evidence for axonal membrane hyperpolarization in multifocal motor neuropathy with conduction block, Brain"}],"container-title":["Muscle &amp; 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