{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:10:25Z","timestamp":1778512225015,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korean Society for Clinical Neurophysiology"},{"name":"Hanmi Pharmaceutical Co., Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p><jats:italic>Introduction<\/jats:italic>: Thyrotoxic periodic paralysis (TPP) is characterized by recurrent episodes of reversible paralysis with hyperthyroidism. It is clinically similar to hypokalemic periodic paralysis (HOPP), which features significant ion\u2010channel dysfunction and reduced muscle fiber conduction velocity (MFCV). However, the muscle membrane function in TPP is not known. <jats:italic>Methods<\/jats:italic>: For 13 patients with TPP and 15 age\u2010matched controls, clinical assessment and serial neurophysiological testing, including nerve conduction, prolonged exercise (PE) testing, and MFCV. were performed. <jats:italic>Results<\/jats:italic>: MFCV values were elevated up to 1 year from the paralytic attack in TPP patients. In the group with a positive PE test, MFCV values were higher. There was no significant relationship between MFCV values and either hypokalemia or hyperthyroidism. <jats:italic>Conclusions<\/jats:italic>: Although clinical manifestations in TPP are similar to those observed in HOPP, TPP appears to feature an alternate pathogenic mechanism. Specifically, MFCV values increased rather than decreased. Further studies are needed to support these findings. <jats:italic>Muscle Nerve<\/jats:italic>, 2016 <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>56<\/jats:bold>: 780\u2013786, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25532","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T14:30:32Z","timestamp":1482589832000},"page":"780-786","source":"Crossref","is-referenced-by-count":1,"title":["Is thyrotoxic periodic paralysis a disease caused by muscle membrane dysfunction?"],"prefix":"10.1002","volume":"56","author":[{"given":"Yoo\u2010Ri","family":"Son","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital, Seoul National University College of Medicine 166 Gumi\u2010Ro Bundang\u2010Gu, Seongnam\u2010Si, Geonggi\u2010Do Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam\u2010Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Dongguk University Ilsan Hospital Goyangsi Gyeonggido Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Gun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital, Seoul National University College of Medicine 166 Gumi\u2010Ro Bundang\u2010Gu, Seongnam\u2010Si, Geonggi\u2010Do Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital, Seoul National University College of Medicine 166 Gumi\u2010Ro Bundang\u2010Gu, Seongnam\u2010Si, Geonggi\u2010Do Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/649502"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldr030"},{"key":"e_1_2_6_4_1","first-page":"274","article-title":"Thyrotoxic periodic paralysis: clinical and molecular aspects","volume":"43","author":"Falhammar H","year":"2013","journal-title":"Endocrine"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000342387.65477.46"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012010046"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.249656"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/93.3.445"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880090805"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200007)23:7<1089::AID-MUS12>3.0.CO;2-Q"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20865"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.07.036"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1997.tb00274.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880170809"},{"key":"e_1_2_6_15_1","first-page":"1132","article-title":"Improvement of the exercise test after therapy in thyrotoxic periodic paralysis","volume":"16","author":"Links TP","year":"1993","journal-title":"Muscle Nerve"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1453"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20884"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(89)90263-0"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10519"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)90536-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480130015001"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00311396"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0339-0"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(93)90069-2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-006-0569-z"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(98)00129-1"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10169"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.37.5.548"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21390"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.518"}],"container-title":["Muscle &amp; 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