{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:28:53Z","timestamp":1783351733028,"version":"3.54.6"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science and Innovation of Spain","award":["SAF2012-40075-C02-01"],"award-info":[{"award-number":["SAF2012-40075-C02-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To better understand the pathophysiology of chronic muscle pain, there are multiple animal models that mimic different acute\/chronic pain conditions, such as carrageenan injection. Our previous studies demonstrated differences between muscles of different innervation in acute pain. In this study we characterized the effect of carrageenan in 2 muscles: masseter (trigeminal innervation) and gastrocnemius (spinal innervation).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Carrageenan (3%, 6%, and 9%) was injected into the masseter and gastrocnemius of rats. Mechanical, heat, and chemical nociceptive thresholds were measured for 14 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Carrageenan did not induce mechanical allodynia or thermal hypersensitivity in either muscle. Instead, it induced a short\u2010lasting mechanical hyperalgesia, greater in the masseter than in the gastrocnemius.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Carrageenan injected into the masseter and gastrocnemius induces a short\u2010lasting hyperalgesia. These results could indicate a higher susceptibility of orofacial muscles to this type of insult and, consequently, a difference between trigeminal and spinal innervation. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>56<\/jats:bold>: 804\u2013813, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25538","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T10:49:55Z","timestamp":1482835795000},"page":"804-813","source":"Crossref","is-referenced-by-count":14,"title":["Characterization of the nociceptive effect of carrageenan: Masseter versus gastrocnemius"],"prefix":"10.1002","volume":"56","author":[{"given":"Ana","family":"Bag\u00fc\u00e9s","sequence":"first","affiliation":[{"name":"\u00c1rea de Farmacolog\u00eda y Nutrici\u00f3n, Unidad asociada I+D+i al Instituto de Qu\u00edmica M\u00e9dica, Grupo de excelencia investigadora URJC\u2013Banco de Santander\u2013Grupo Multidisciplinar de Investigaci\u00f3n y Tratamiento del Dolor (i+DOL) Alcorc\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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