{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:51:27Z","timestamp":1782964287440,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Cognitive fatigue has frequently been reported in myasthenia gravis (MG). However, objective assessment of cognitive fatigability has never been evaluated. <jats:italic>Methods<\/jats:italic>: Thirty\u2010three MG patients with stable generalized disease and 17 healthy controls underwent a test battery including repeated testing of attention and concentration (d2\u2010R) and Paced Auditory Serial Addition Test. Fatigability was based on calculation of linear trend (LT) reflecting dynamic performance within subsequent constant time intervals. Additionally, fatigue questionnaires were used. <jats:italic>Results<\/jats:italic>: MG patients showed a negative LT in second d2\u2010R testing, indicating cognitive fatigability. This finding significantly differed from stable cognitive performance in controls (<jats:italic>P<\/jats:italic> &lt; 0.05). Results of Paced Auditory Serial Addition Test testing did not differ between groups. Self\u2010assessed fatigue was significantly higher in MG patients compared with controls (<jats:italic>P<\/jats:italic> &lt; 0.001), but did not correlate with LT. <jats:italic>Conclusions<\/jats:italic>: LT quantifies cognitive fatigability as an objective measurement of performance decline in MG patients. Self\u2010assessed cognitive fatigue is not correlated with objective findings. <jats:italic>Muscle Nerve<\/jats:italic> 56: 449\u2013457, 2017<\/jats:p>","DOI":"10.1002\/mus.25540","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T23:27:01Z","timestamp":1483054021000},"page":"449-457","source":"Crossref","is-referenced-by-count":26,"title":["Cognitive fatigue in patients with myasthenia gravis"],"prefix":"10.1002","volume":"56","author":[{"given":"Berit","family":"Jordan","sequence":"first","affiliation":[{"name":"Department of Neurology Martin\u2010Luther\u2010University Halle Ernst\u2010Grube\u2010Strasse 40 06097 Halle\/Saale Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabea L.K.","family":"Schweden","sequence":"additional","affiliation":[{"name":"Institute of Psychology Martin\u2010Luther\u2010University Halle Halle\/Saale Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Mehl","sequence":"additional","affiliation":[{"name":"Department of Neurology Martin\u2010Luther\u2010University Halle Ernst\u2010Grube\u2010Strasse 40 06097 Halle\/Saale Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Menge","sequence":"additional","affiliation":[{"name":"Institute of Psychology Martin\u2010Luther\u2010University Halle Halle\/Saale Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Zierz","sequence":"additional","affiliation":[{"name":"Department of Neurology Martin\u2010Luther\u2010University Halle Ernst\u2010Grube\u2010Strasse 40 06097 Halle\/Saale Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827f07be"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-132"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.538"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00205-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-156-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(00)00052-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200009)23:9<1402::AID-MUS11>3.0.CO;2-B"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1054\/jocn.2001.1016"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01376517-200304000-00004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1988.tb05148.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.12.4.499"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25386"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.16"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(99)80001-6"},{"key":"e_1_2_6_16_1","volume-title":"D2\u2010R Attention stress test","author":"Brickencamp R","year":"2010"},{"key":"e_1_2_6_17_1","unstructured":"MuellerST.PEBL: The Psychology Experiment Building Language (version 0.12)[Computer experiment programming language]. 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