{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T15:49:13Z","timestamp":1694706553495},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In this study we assess the Italian version of the 15\u2010item Myasthenia Gravis Quality\u2010of\u2010Life questionnaire (MG\u2010QOL15).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The validation protocol included the MG\u2010QOL15, the 36\u2010item Short Form (SF\u201036), the Besta Neurological Institute Rating Scale for Myasthenia Gravis, and the MG\u2010Composite. We used the Cronbach \u03b1 to test reliability, the Spearman correlation to test short\u2010term test\u2013retest, the Kruskal\u2013Wallis test to assess differences in MG\u2010QOL15 between patients with different disease severity, and the Wilcoxon signed\u2010rank test to assess sensitivity to change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010two patients were enrolled in the study. The mean MG\u2010QOL15 score was 15.2\u2009\u00b1\u200912.2, with \u03b1\u2009=\u20090.93 and test\u2013retest correlation\u2009=\u20090.93. Compared with the SF\u201036, the MG\u2010QOL15 was superior in differentiating patients with different MG types (<jats:italic>P<\/jats:italic>\u2009=\u20090.041) and severity (<jats:italic>P<\/jats:italic>\u2009=\u20090.004), showed higher sensitivity to change (<jats:italic>P<\/jats:italic>\u2009=\u20090.003 for improved and <jats:italic>P<\/jats:italic>\u2009=\u20090.024 for worsened patients), and had higher correlations with the MG\u2010Composite (rho\u2009=\u20090.367 vs. \u20130.213 and \u20130.154).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Italian version of the MG\u2010QOL15 is valid, reliable, stable, and sensitive to changes. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>56<\/jats:bold>: 716\u2013720, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25545","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T16:23:37Z","timestamp":1482942217000},"page":"716-720","source":"Crossref","is-referenced-by-count":8,"title":["Validation of the italian version of the 15\u2010item Myasthenia Gravis Quality\u2010of\u2010Life questionnaire"],"prefix":"10.1002","volume":"56","author":[{"given":"Alberto","family":"Raggi","sequence":"first","affiliation":[{"name":"Neurology, Public Health and Disability Unit, Neurological Institute C. Besta IRCCS Foundation Via Celoria 11, 20133 Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Neurology, Public Health and Disability Unit, Neurological Institute C. Besta IRCCS Foundation Via Celoria 11, 20133 Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Ayadi","sequence":"additional","affiliation":[{"name":"Neurology, Public Health and Disability Unit, Neurological Institute C. Besta IRCCS Foundation Via Celoria 11, 20133 Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Antozzi","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology and Neuromuscular Disorders Neurological Institute C. Besta IRCCS Foundation Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Maggi","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology and Neuromuscular Disorders Neurological Institute C. Besta IRCCS Foundation Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulvio","family":"Baggi","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology and Neuromuscular Disorders Neurological Institute C. Besta IRCCS Foundation Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Mantegazza","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology and Neuromuscular Disorders Neurological Institute C. 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