{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:24:43Z","timestamp":1759479883980,"version":"3.41.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We sought to verify whether isoflavin\u2010beta (Iso\u2010\u03b2), a mixture of isoflavones with antioxidant properties, could prevent thyrotoxicosis\u2010induced loss of muscle mass and the participation of oxidative stress (OS) in the mechanisms of this prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two experimental periods of thyrotoxicosis induction were used in Wistar rats: 3 and 5 days to assess Iso\u2010\u03b2 effects before and after thyrotoxicosis\u2010induced muscle wasting. After euthanasia, peritoneal fat and gastrocnemius muscle were collected, weighed, and muscle OS was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Iso\u2010\u03b2 prevented the loss of gastrocnemius mass in thyrotoxic rats through the prevention of muscle OS generation during thyrotoxicosis, increasing muscle total antioxidant capacity and decreasing mitochondrial cytochrome c oxidase activity, lipid peroxidation, and protein carbonyl content.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Iso\u2010\u03b2 decreased oxidative modification of proteins, which is known to exert a major role during proteolysis induction and is present in thyrotoxic myopathy, highlighting the potential action of Iso\u2010\u03b2 in this complication of the disease.<jats:italic>Muscle Nerve<\/jats:italic><jats:bold>56<\/jats:bold>: 975\u2013981, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25546","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T16:23:22Z","timestamp":1482942202000},"page":"975-981","source":"Crossref","is-referenced-by-count":7,"title":["Isoflavin\u2010\u03b2 modifies muscle oxidative stress and prevents a thyrotoxicosis\u2010induced loss of muscle mass in rats"],"prefix":"10.1002","volume":"56","author":[{"given":"Poliana C.","family":"Marinello","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Pathology, State University of Londrina, Rodovia Celso Garcia Cid, PR445, Km 380 Campus Universit\u00e1rio Londrina CEP 86051\u2010990 Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara S.","family":"Bernardes","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pathology, State University of Londrina, Rodovia Celso Garcia Cid, PR445, Km 380 Campus Universit\u00e1rio Londrina CEP 86051\u2010990 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