{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:47:18Z","timestamp":1790034438348,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"name":"Vattikuti Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle Nerve"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1002\/mus.25564","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T08:54:59Z","timestamp":1483779299000},"page":"197-201","source":"Crossref","is-referenced-by-count":14,"title":["Dysfunction of central control of breathing in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"56","author":[{"given":"Bradley N.","family":"Howell","sequence":"first","affiliation":[{"name":"Department of Neurology; Henry Ford Hospital; 2799 W Grand Boulevard, CFP 460 Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Neurology; Henry Ford Hospital; 2799 W Grand Boulevard, CFP 460 Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"10.1002\/mus.25564-BIB0001|mus25564-cit-0001","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3109\/21678421.2012.745568","article-title":"Non-invasive ventilation in amyotrophic lateral sclerosis","volume":"14","author":"Vrijsen","year":"2013","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1002\/mus.25564-BIB0002|mus25564-cit-0002","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1212\/WNL.0b013e3181bc01a4","article-title":"Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive\/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"73","author":"Miller","year":"2009","journal-title":"Neurology"},{"key":"10.1002\/mus.25564-BIB0003|mus25564-cit-0003","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-8993(79)90739-X","article-title":"Afferent projections to the inspiratory neuronal region of the ventrolateral nucleus of the tractus solitarius in the cat","volume":"171","author":"Kalia","year":"1979","journal-title":"Brain Res"},{"key":"10.1002\/mus.25564-BIB0004|mus25564-cit-0004","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1113\/jphysiol.1923.sp002052","article-title":"Observations on the respiratory centres in the cat","volume":"57","author":"Lumsden","year":"1923","journal-title":"J Physiol"},{"key":"10.1002\/mus.25564-BIB0005|mus25564-cit-0005","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1113\/jphysiol.1984.sp015370","article-title":"Respiratory rhythm generation in the in vitro brain stem-spinal cord preparation of the neonatal rat","volume":"354","author":"Suzue","year":"1984","journal-title":"J Physiol"},{"key":"10.1002\/mus.25564-BIB0006|mus25564-cit-0006","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1126\/science.1683005","article-title":"Pre-Botzinger complex: a brainstem region that may generate respiratory rhythm in mammals","volume":"254","author":"Smith","year":"1991","journal-title":"Science"},{"key":"10.1002\/mus.25564-BIB0007|mus25564-cit-0007","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/brain\/awq327","article-title":"Neuroanatomical characteristics of the human pre-B\u00f6tzinger complex and its involvement in neurodegenerative brainstem diseases","volume":"134","author":"Schwarzacher","year":"2011","journal-title":"Brain"},{"key":"10.1002\/mus.25564-BIB0008|mus25564-cit-0008","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1523\/JNEUROSCI.23-04-01478.2003","article-title":"A novel functional neuron group for respiratory rhythm generation in the ventral medulla","volume":"23","author":"Onimaru","year":"2003","journal-title":"J Neurosci"},{"key":"10.1002\/mus.25564-BIB0009|mus25564-cit-0009","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1113\/jphysiol.2005.098848","article-title":"Distinct rhythm generators for inspiration and expiration in the juvenile rat","volume":"570","author":"Janczewski","year":"2006","journal-title":"J Physiol"},{"key":"10.1002\/mus.25564-BIB0010|mus25564-cit-0010","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0896-6273(03)00092-8","article-title":"Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation","volume":"37","author":"Mellen","year":"2003","journal-title":"Neuron"},{"key":"10.1002\/mus.25564-BIB0011|mus25564-cit-0011","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/mds.21236","article-title":"Brainstem respiratory control: substrates of respiratory failure of multiple system atrophy","volume":"22","author":"Benarroch","year":"2007","journal-title":"Mov Disord"},{"key":"10.1002\/mus.25564-BIB0012|mus25564-cit-0012","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nn0901-927","article-title":"Normal breathing requires preB\u00f6tzinger complex neurokinin-1 receptor-expressing neurons","volume":"4","author":"Gray","year":"2001","journal-title":"Nat Neurosci"},{"key":"10.1002\/mus.25564-BIB0013|mus25564-cit-0013","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/nn1517","article-title":"Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons","volume":"8","author":"McKay","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1002\/mus.25564-BIB0014|mus25564-cit-0014","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0954-6111(03)00188-4","article-title":"Sleep breathing disorders in patients with idiopathic Parkinson's disease","volume":"97","author":"Maria","year":"2003","journal-title":"Respir Med"},{"key":"10.1002\/mus.25564-BIB0015|mus25564-cit-0015","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1093\/brain\/awg220","article-title":"Depletion of ventromedullary NK-1 receptor-immunoreactive neurons in multiple system atrophy","volume":"126","author":"Benarroch","year":"2003","journal-title":"Brain"},{"key":"10.1002\/mus.25564-BIB0016|mus25564-cit-0016","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ana.23937","article-title":"Stages of pTDP-43 pathology in amyotrophic lateral sclerosis","volume":"74","author":"Brettschneider","year":"2013","journal-title":"Ann Neurol"},{"key":"10.1002\/mus.25564-BIB0017|mus25564-cit-0017","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrn3121","article-title":"Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration","volume":"13","author":"Lee","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"10.1002\/mus.25564-BIB0018|mus25564-cit-0018","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.tins.2014.05.006","article-title":"Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies","volume":"37","author":"Vucic","year":"2014","journal-title":"Trends Neurosci"},{"key":"10.1002\/mus.25564-BIB0019|mus25564-cit-0019","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1001\/archneurpsyc.1953.02320260029002","article-title":"Amyotrophic lateral sclerosis","volume":"69","author":"Lawyer","year":"1953","journal-title":"AMA Arch Neurol Psychiatry"},{"key":"10.1002\/mus.25564-BIB0020|mus25564-cit-0020","first-page":"210","article-title":"Preservation of the nucleus X-pelvic floor motosystem in amyotrophic lateral sclerosis","volume":"3","author":"Schroder","year":"1984","journal-title":"Clin Neuropathol"},{"key":"10.1002\/mus.25564-BIB0021|mus25564-cit-0021","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2990.1993.tb00443.x","article-title":"Parvalbumin and calbindin D-28k in the human motor system and in motor neuron disease","volume":"19","author":"Ince","year":"1993","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1002\/mus.25564-BIB0022|mus25564-cit-0022","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/ana.410360608","article-title":"The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis","volume":"36","author":"Alexianu","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1002\/mus.25564-BIB0023|mus25564-cit-0023","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1023\/A:1025799830302","article-title":"Parvalbumin in respiratory neurons of the ventrolateral medulla of the adult rat","volume":"31","author":"Alheid","year":"2002","journal-title":"J Neurocytol"},{"key":"10.1002\/mus.25564-BIB0024|mus25564-cit-0024","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1001\/archinte.1965.03860140072016","article-title":"Motor system disease: review and discussion of a case presenting with alveolar hypoventilation","volume":"115","author":"Serpick","year":"1965","journal-title":"Arch Intern Med"},{"key":"10.1002\/mus.25564-BIB0025|mus25564-cit-0025","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/17482960903207385","article-title":"Electrophysiological assessment of corticorespiratory pathway function in amyotrophic lateral sclerosis","volume":"11","author":"Shimizu","year":"2010","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1002\/mus.25564-BIB0026|mus25564-cit-0026","first-page":"40","article-title":"A study on sleep in amyotrophic lateral sclerosis","volume":"30","author":"Minz","year":"1979","journal-title":"Biomedicine \/ [publiee pour l'AAICIG]"},{"key":"10.1002\/mus.25564-BIB0027|mus25564-cit-0027","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1378\/chest.93.6.1309","article-title":"Amyotrophic lateral sclerosis presenting with sleep hypopnea syndrome","volume":"93","author":"Carre","year":"1988","journal-title":"Chest"},{"key":"10.1002\/mus.25564-BIB0028|mus25564-cit-0028","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/S0022-510X(97)00241-4","article-title":"Polysomnographic studies in amyotrophic lateral sclerosis","volume":"152","author":"David","year":"1997","journal-title":"J Neurol Sci"},{"key":"10.1002\/mus.25564-BIB0029|mus25564-cit-0029","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1378\/chest.110.3.664","article-title":"Sleep-disordered breathing in amyotrophic lateral sclerosis","volume":"110","author":"Ferguson","year":"1996","journal-title":"Chest"},{"key":"10.1002\/mus.25564-BIB0030|mus25564-cit-0030","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1164\/ajrccm.161.3.9805008","article-title":"Sleep disorders and diaphragmatic function in patients with amyotrophic lateral sclerosis","volume":"161","author":"Arnulf","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/mus.25564-BIB0031|mus25564-cit-0031","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/17482960601029883","article-title":"Sleep characteristics of amyotrophic lateral sclerosis in patients with preserved diaphragmatic function","volume":"8","author":"Atalaia","year":"2007","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1002\/mus.25564-BIB0032|mus25564-cit-0032","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/17482960802382305","article-title":"Percutaneous nocturnal oximetry in amyotrophic lateral sclerosis: periodic desaturation","volume":"10","author":"Carvalho","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1002\/mus.25564-BIB0033|mus25564-cit-0033","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.amjsurg.2014.10.008","article-title":"Identification of unexpected respiratory abnormalities in patients with amyotrophic lateral sclerosis through electromyographic analysis using intramuscular electrodes implanted for therapeutic diaphragmatic pacing","volume":"209","author":"Onders","year":"2015","journal-title":"Am J Surg"},{"key":"10.1002\/mus.25564-BIB0034|mus25564-cit-0034","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/S0025-6196(12)62080-1","article-title":"Effects of alterations in pulmonary function and sleep variables on survival in patients with amyotrophic lateral sclerosis","volume":"66","author":"Gay","year":"1991","journal-title":"Mayo Clin Proc"},{"key":"10.1002\/mus.25564-BIB0035|mus25564-cit-0035","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1164\/ajrccm.164.12.2107045","article-title":"Sleep apnea and cardiovascular disease","volume":"164","author":"Leung","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1002\/mus.25564-BIB0036|mus25564-cit-0036","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0022-510X(94)90009-4","article-title":"Circulatory collapse and sudden death in respirator-dependent amyotrophic lateral sclerosis","volume":"124","author":"Shimizu","year":"1994","journal-title":"J Neurol Sci"},{"key":"10.1002\/mus.25564-BIB0037|mus25564-cit-0037","first-page":"149","article-title":"Selective vulnerability in brain hypoxia","volume":"6","author":"Cervos-Navarro","year":"1991","journal-title":"Crit Rev Neurobiol"},{"key":"10.1002\/mus.25564-BIB0038|mus25564-cit-0038","doi-asserted-by":"crossref","first-page":"e75324","DOI":"10.1371\/journal.pone.0075324","article-title":"Nocturnal hypoxia in ALS is related to cognitive dysfunction and can occur as clusters of desaturations","volume":"8","author":"Park","year":"2013","journal-title":"PLoS One"},{"key":"10.1002\/mus.25564-BIB0039|mus25564-cit-0039","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.apmr.2012.08.215","article-title":"Home-based overnight transcutaneous capnography\/pulse oximetry for diagnosing nocturnal hypoventilation associated with neuromuscular disorders","volume":"94","author":"Bauman","year":"2013","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1002\/mus.25564-BIB0040|mus25564-cit-0040","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.rmed.2010.10.007","article-title":"Transcutaneous monitoring as a replacement for arterial PCO(2) monitoring during nocturnal non-invasive ventilation","volume":"105","author":"Storre","year":"2011","journal-title":"Respir Med"},{"key":"10.1002\/mus.25564-BIB0041|mus25564-cit-0041","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/B978-1-4160-4710-0.00078-X","volume-title":"Murray and Nadel's textbook of respiratory medicine","author":"Duffin","year":"2010","edition":"5"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.25564","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/mus.25564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T04:56:38Z","timestamp":1625460998000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.25564"}},"subtitle":["Issues &amp; Opinions: Dysfunction of Central Control"],"short-title":[],"issued":{"date-parts":[[2017,3,24]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,8]]}},"URL":"https:\/\/doi.org\/10.1002\/mus.25564","archive":["Portico"],"relation":{},"ISSN":["0148-639X"],"issn-type":[{"value":"0148-639X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3,24]]}}}