{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T19:56:20Z","timestamp":1722887780219},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institutes of Health-National Institute of Neurological Disorders and Stroke","award":["5 P30 NS047463"],"award-info":[{"award-number":["5 P30 NS047463"]}]},{"name":"National Institutes of Health-National Cancer Institute","award":["P30 CA016059"],"award-info":[{"award-number":["P30 CA016059"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Late revision nerve surgery for incomplete motor recovery due to partial reinnervation would improve muscle function if all muscle fibers were protected from developing denervation atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty immature Sprague\u2010Dawley rats underwent the following tibial nerve manipulations (<jats:italic>n<\/jats:italic>\u2009=\u200915\/group): group A, partial denervation (two thirds of nerve resected and the remaining one third crushed), revision repair at 8 months; group B, partial denervation; group C, complete denervation, immediate reconstruction; group D, complete denervation, reconstruction at 8 months; and group E, control. Final testing at 11 months included muscle force, weight, and histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Muscle weight was significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) different among all groups (highest to lowest: E\u2009&gt;\u2009B\u2009&gt;\u2009C\u2009&gt;\u2009A\u2009&gt;\u2009D), and force was significantly lower in groups A and D compared with E. Muscle fiber cross\u2010sectional area was statistically smaller in group A than in groups B, C, or E.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Partial reinnervation still allowed substantial muscle recovery, but it did not preserve the non\u2010innervated muscle fibers. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>56<\/jats:bold>: 1143\u20131148, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25571","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T23:28:11Z","timestamp":1484090891000},"page":"1143-1148","source":"Crossref","is-referenced-by-count":5,"title":["Does partial muscle reinnervation preserve future re\u2010innervation potential?"],"prefix":"10.1002","volume":"56","author":[{"given":"Jonathan","family":"Isaacs","sequence":"first","affiliation":[{"name":"Division of Hand Surgery, Department of Orthopaedic Surgery Virginia Commonwealth University Medical Center 1200 East Broad Street, Richmond 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