{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:16:00Z","timestamp":1790169360555,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/21321"],"award-info":[{"award-number":["2013\/21321"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>It is not clear if electrical stimulation (ES) can affect muscle reinnervation. This study aimed to verify if ES affects neuromuscular recovery after nerve crush injury in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Denervated muscles were electrically stimulated daily for 6 or 14 days. Neuromuscular performance and excitability, and muscle morphology were determined. Muscle trophism markers (atrogin\u20101, MuRF\u20101, and myoD), as well as neuromuscular junction (NMJ) organization (muscle\u2010specific receptor tyrosine kinase [MuSK], cytoplasmic protein downstream of kinase\u20107 [Dok\u20107], nicotinic ACh receptor [nAChR], and neural cell adhesion molecule [N\u2010CAM]) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ES impaired neuromuscular recovery at day 14 postdenervation. Muscle hypoexcitability was accentuated by ES at 6 and 14 days postdenervation. Although ES reduced the accumulation of atrogin\u20101, MuRF1, and myoD mRNAs, it increased muscle atrophy. Gene expression of MuSK, Dok\u20107, nAChR, and the content of N\u2010CAM protein were altered by ES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>ES can delay the reinnervation process by modulating factors related to NMJ stability and organization, and inducing dysfunction, hypoexcitability, and muscle atrophy. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>56<\/jats:bold>: E108\u2013E118, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25589","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T03:33:03Z","timestamp":1485315183000},"source":"Crossref","is-referenced-by-count":15,"title":["Electrical stimulation delays reinnervation in denervated rat muscle"],"prefix":"10.1002","volume":"56","author":[{"given":"Clara M.","family":"Pinheiro\u2010Dardis","sequence":"first","affiliation":[{"name":"Fisioterapia Neurol\u00f3gica (LaFiN), Departamento de Fisioterapia, Universidade Federal de S\u00e3o Carlos (UFSCar), Rodovia Washington Luis Km 235, C.P. 676 \u2013 CEP: 13565\u2010905, S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna T.","family":"Erbereli","sequence":"additional","affiliation":[{"name":"Fisioterapia Neurol\u00f3gica (LaFiN), Departamento de Fisioterapia, Universidade Federal de S\u00e3o Carlos (UFSCar), Rodovia Washington Luis Km 235, C.P. 676 \u2013 CEP: 13565\u2010905, S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davilene","family":"Gigo\u2010Benato","sequence":"additional","affiliation":[{"name":"Fisioterapia Neurol\u00f3gica (LaFiN), Departamento de Fisioterapia, Universidade Federal de S\u00e3o Carlos (UFSCar), Rodovia Washington Luis Km 235, C.P. 676 \u2013 CEP: 13565\u2010905, S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula A.T.S.","family":"Castro","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle Plasticity, 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