{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T09:22:04Z","timestamp":1777195324674,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,8]],"date-time":"2017-04-08T00:00:00Z","timestamp":1491609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Science and Technology of Guizhou Province, China","award":["J[2015]2015"],"award-info":[{"award-number":["J[2015]2015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We assessed antibodies against low\u2010density lipoprotein receptor\u2010related protein 4 (LRP4\u2010Ab) in a Chinese population with myasthenia gravis (MG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum samples from 116 patients and 80 controls were collected. Acetylcholine receptor antibodies(AChR\u2010Ab) and muscle\u2010specific receptor tyrosine kinase antibodies (MuSK\u2010Ab) were tested using an enzyme\u2010linked immune absorption assay, and LRP4\u2010Ab was identified using a cell\u2010based assay. MG patients with neither AChR\u2010Ab nor MuSK\u2010Ab were defined as double\u2010seronegative MG (dSN\u2010MG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two of 116 (1.7%) of all patients and 2 of 50 (1%) dSN\u2010MG patients were positive for LRP4\u2010Ab. These 2 patients had ocular MG. Following treatment with acetylcholinesterase inhibitor and prednisone, both achieved full remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows that LRP4\u2010Ab is a pathogenic antibody in MG. LRP4\u2010MG seems to be characterized by mild disease severity and favorable therapeutic effect in contrast with other types of MG. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>56<\/jats:bold>: 938\u2013942, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25591","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T03:34:06Z","timestamp":1485315246000},"page":"938-942","source":"Crossref","is-referenced-by-count":33,"title":["Anti\u2010LRP4 autoantibodies in Chinese patients with myasthenia gravis"],"prefix":"10.1002","volume":"56","author":[{"given":"Yuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Guizhou Medical University No. 28, Gui Yi Street, Guiyang Guizhou Province 550004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Guizhou Medical University No. 28, Gui Yi Street, Guiyang Guizhou Province 550004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Guizhou Medical University No. 28, Gui Yi Street, Guiyang Guizhou Province 550004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dian","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Guizhou Medical University No. 28, Gui Yi Street, Guiyang Guizhou Province 550004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqing","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Guizhou Medical University No. 28, Gui Yi Street, Guiyang Guizhou Province 550004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Guizhou Medical University No. 28, Gui Yi Street, Guiyang Guizhou Province 550004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Guizhou Medical University No. 28, Gui Yi Street, Guiyang Guizhou Province 550004 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70063-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.03.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880171208"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.12.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.2393"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22312"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.03.013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6194-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2015-001126"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.2032"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06833.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.12.011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.03.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182407982"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.279307"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.10.006"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.002"},{"key":"e_1_2_7_20_1","first-page":"257","article-title":"Acetylcholine receptor antibody characteristics in myasthenia gravis. 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