{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:41:26Z","timestamp":1771674086259,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: In compressive neuropathies, large myelinated nerve fibers are generally thought to be more susceptible. In this study, we investigated small myelinated A\u03b4 and unmyelinated C fiber function in patients with mild, moderate, and severe carpal tunnel syndrome. <jats:italic>Methods<\/jats:italic>: Forty\u2010four healthy controls and 81 carpal tunnel syndrome patients in the mild, moderate, or severe categories were recruited. Small fiber sensation in the affected hand was determined with quantitative sensory testing. <jats:italic>Results<\/jats:italic>: Cold detection thresholds in the severe carpal tunnel syndrome group (18.9 \u00b1 6.8\u00b0C) were significantly impaired compared with controls (27.2 \u00b1 2.1\u00b0C) (<jats:italic>P<\/jats:italic> &lt; 0.01). Similarly, warm detection thresholds were also impaired in the severe carpal tunnel syndrome group (41.2 \u00b1 3.5\u00b0C) compared with control (37.1 \u00b1 2.1\u00b0C) (<jats:italic>P<\/jats:italic> &lt; 0.01). <jats:italic>Conclusions<\/jats:italic>: These results support the growing body of evidence that carpal tunnel syndrome can affect small afferent fibers. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>56<\/jats:bold>: 814\u2013816, 2017<\/jats:p>","DOI":"10.1002\/mus.25592","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T15:47:42Z","timestamp":1485532062000},"page":"814-816","source":"Crossref","is-referenced-by-count":12,"title":["Assessment of small sensory fiber function across the spectrum of severity in carpal tunnel syndrome patients"],"prefix":"10.1002","volume":"56","author":[{"given":"Christopher","family":"Clarke","sequence":"first","affiliation":[{"name":"Division of Physical Medicine and Rehabilitation Faculty of Medicine and Dentistry, University of Alberta Edmonton Alberta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Christensen","sequence":"additional","affiliation":[{"name":"Division of Physical Medicine and Rehabilitation Faculty of Medicine and Dentistry, University of Alberta Edmonton Alberta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew W.T.","family":"Curran","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Faculty of Medicine and Dentistry, University of Alberta Edmonton Alberta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Ming","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Physical Medicine and Rehabilitation Faculty of Medicine and Dentistry, University of Alberta Edmonton Alberta"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.2.153"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(72)90026-3"},{"key":"e_1_2_7_4_1","first-page":"154","article-title":"Palmar cold threshold test and median nerve electrophysiology in carpal tunnel compression neuropathy","volume":"28","author":"Westerman RA","year":"1991","journal-title":"Clin Exp Neurol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1996.tb07061.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.05.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-009-0213-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.06.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu288"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880170608"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00131-W"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880180210"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-009-1941-z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31821c29d3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.11.1589"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1508"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90239-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1988.tb03698.x"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.25592","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.25592","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.25592","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.25592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T01:54:45Z","timestamp":1693965285000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.25592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,21]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/mus.25592"],"URL":"https:\/\/doi.org\/10.1002\/mus.25592","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,21]]}}}