{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:11:30Z","timestamp":1777003890711,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009657","name":"FSHD Global Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009657","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5U54HD060848"],"award-info":[{"award-number":["5U54HD060848"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> Herein we provide a comprehensive overview of bone health in facioscapulohumeral muscular dystrophy (FSHD). <jats:italic>Methods<\/jats:italic>: Ninety\u2010four adult individuals with FSHD type 1 from 2 sites were included in this cross\u2010sectional study. Clinical characteristics and determinants of bone health were examined. Relationships between bone mineral density (BMD), strength, and function were explored. <jats:italic>Results<\/jats:italic>: Nearly a third of subjects were deficient in vitamin D<jats:sub>3<\/jats:sub>. Mean whole\u2010body BMD <jats:italic>z<\/jats:italic>\u2010score was \u22120.7; 11% of subjects had greater than age\u2010related reductions in whole\u2010body BMD (<jats:italic>z<\/jats:italic>\u2010score &lt; \u22122.0). Whole\u2010body and regional BMDs were associated with strength and function. Thirty\u2010six percent had a history of fractures. Likelihood of fractures was reduced for those with normal whole\u2010body BMD (odds ratio = 0.25, 95% confidence interval 0.04\u20130.78). <jats:italic>Discussion<\/jats:italic>: A diagnosis of FSHD is not necessarily predictive of reduced BMD or increased fracture rate. Given the considerable variability of bone health in the FSHD population, strength and function can serve as predictors of BMD. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>56<\/jats:bold>: 1108\u20131113, 2017<\/jats:p>","DOI":"10.1002\/mus.25619","type":"journal-article","created":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T16:02:43Z","timestamp":1487433763000},"page":"1108-1113","source":"Crossref","is-referenced-by-count":15,"title":["Bone health in facioscapulohumeral muscular dystrophy: A cross\u2010sectional study"],"prefix":"10.1002","volume":"56","author":[{"given":"Hema","family":"Chagarlamudi","sequence":"first","affiliation":[{"name":"Center for Genetic Muscle Disorders Kennedy Krieger Institute Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alastair","family":"Corbett","sequence":"additional","affiliation":[{"name":"The Concord Hospital Concord New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Stoll","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory Concord Hospital Concord New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genila","family":"Bibat","sequence":"additional","affiliation":[{"name":"Center for Genetic Muscle Disorders Kennedy Krieger Institute Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Grosmann","sequence":"additional","affiliation":[{"name":"Center for Genetic Muscle Disorders Kennedy Krieger Institute Baltimore Maryland USA"},{"name":"Rady Children's Hospital and Department of Neurosciences University of California San Diego School of Medicine San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carly","family":"Matichak Stock","sequence":"additional","affiliation":[{"name":"Center for Genetic Muscle Disorders Kennedy Krieger Institute Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikia","family":"Stinson","sequence":"additional","affiliation":[{"name":"Center for Genetic Muscle Disorders Kennedy Krieger Institute Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Osteogenesis Imperfecta Department Kennedy Krieger Institute Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn R.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Center for Genetic Muscle Disorders Kennedy Krieger Institute Baltimore Maryland USA"},{"name":"Department of Neurology The Johns Hopkins School of Medicine Baltimore Maryland USA"},{"name":"Department of Neuroscience The Johns Hopkins School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"What's in a name? 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