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As chronic inflammation and stress are implicated in DMD pathology, the efficacy of an anti\u2010inflammatory and anti\u2010stress intervention strategy in ameliorating diaphragm dysfunction was investigated. <jats:italic>Methods<\/jats:italic>: Diaphragm muscle contractile function was compared in wild\u2010type and dystrophin\u2010deficient <jats:italic>mdx<\/jats:italic> mice treated with saline, anti\u2010interleukin\u20106 receptor antibodies (xIL\u20106R), the corticotrophin\u2010releasing factor receptor 2 (CRFR2) agonist, urocortin 2, or both xIL\u20106R and urocortin 2. <jats:italic>Results<\/jats:italic>: Combined treatment with xIL\u20106R and urocortin 2 rescued impaired force in <jats:italic>mdx<\/jats:italic> diaphragms. Mechanical work production and muscle shortening was also improved by combined drug treatment. <jats:italic>Discussion<\/jats:italic>: Treatment which neutralizes peripheral IL\u20106 signaling and stimulates CRFR2 recovers force\u2010generating capacity and the ability to perform mechanical work in <jats:italic>mdx<\/jats:italic> diaphragm muscle. These findings may be important in the search for therapeutic targets in DMD. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>56<\/jats:bold>: E134\u2013E140, 2017<\/jats:p>","DOI":"10.1002\/mus.25644","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T18:24:22Z","timestamp":1489515862000},"source":"Crossref","is-referenced-by-count":8,"title":["Combined XIL\u20106R and urocortin\u20102 treatment restores <i>MDX<\/i> diaphragm muscle force"],"prefix":"10.1002","volume":"56","author":[{"given":"Jennifer","family":"Manning","sequence":"first","affiliation":[{"name":"Department of Physiology, Western Gateway Building University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Physiology, Western Gateway Building University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken 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