{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T17:52:02Z","timestamp":1759513922789},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS086773","P30 NS057105"],"award-info":[{"award-number":["R01 NS086773","P30 NS057105"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> Acellular nerve allografts (ANAs) yield less consistent favorable outcomes compared with autografts for long gap reconstructions. We evaluated whether a hybrid ANA can improve 6\u2010cm gap reconstruction. <jats:italic>Methods:<\/jats:italic> Rat sciatic nerve was transected and repaired with either 6\u2010cm hybrid or control ANAs. Hybrid ANAs were generated using a 1\u2010cm cellular isograft between 2.5\u2010cm ANAs, whereas control ANAs had no isograft. Outcomes were assessed by graft gene and marker expression (<jats:italic>n<\/jats:italic> = 4; at 4 weeks) and motor recovery and nerve histology (<jats:italic>n<\/jats:italic> = 10; at 20 weeks). <jats:italic>Results:<\/jats:italic> Hybrid ANAs modified graft gene and marker expression and promoted modest axon regeneration across the 6\u2010cm defect compared with control ANA (<jats:italic>P<\/jats:italic> &lt; 0.05), but yielded no muscle recovery. Control ANAs had no appreciable axon regeneration across the 6\u2010cm defect. <jats:italic>Discussion:<\/jats:italic> A hybrid ANA confers minimal motor recovery benefits for regeneration across long gaps. Clinically, the authors will continue to reconstruct long nerve gaps with autografts. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>57<\/jats:bold>: 260\u2013267, 2018<\/jats:p>","DOI":"10.1002\/mus.25659","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T23:43:43Z","timestamp":1491435823000},"page":"260-267","source":"Crossref","is-referenced-by-count":17,"title":["Nerve stepping stone has minimal impact in aiding regeneration across long acellular nerve allografts"],"prefix":"10.1002","volume":"57","author":[{"given":"Ying","family":"Yan","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Washington University School of Medicine 660 South Euclid Avenue, Campus Box 8238, St. Louis Missouri 63110 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Washington 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