{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:41:54Z","timestamp":1761896514946},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:00:00Z","timestamp":1494806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Interuniversity Attraction Poles of the Belgian Federal Science Policy Office","award":["P7\/16"],"award-info":[{"award-number":["P7\/16"]}]},{"name":"Flemish Fund for Scientific Research (FWO-Vlaanderen)","award":["E-RARE-2"],"award-info":[{"award-number":["E-RARE-2"]}]},{"name":"ERA-Net for Research on Rare Diseases (PYRAMID)"},{"name":"EU Joint Programme - Neurodegenerative Disease Research (JPND) project (STRENGTH)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTACT<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Disturbances of eye movements are infrequently encountered in motor neuron diseases (MNDs) or motor neuropathies, and there is no known syndrome that combines progressive muscle weakness with downbeat nystagmus. <jats:italic>Methods<\/jats:italic>: To describe the core clinical features of a syndrome of MND associated with downbeat nystagmus, clinical features were collected from 6 patients. <jats:italic>Results<\/jats:italic>: All patients had slowly progressive muscle weakness and wasting in combination with downbeat nystagmus, which was clinically most obvious in downward and lateral gaze. Onset was in the second to fourth decade with finger extension weakness, progressing to other distal and sometimes more proximal muscles. Visual complaints were not always present. Electrodiagnostic testing showed signs of regional motor axonal loss in all patients. <jats:italic>Discussion<\/jats:italic>: The etiology of this syndrome remains elusive. Because finger extension weakness and downbeat nystagmus are the discriminating clinical features of this MND, we propose the name <jats:italic>FEWDON\u2010MND syndrome<\/jats:italic>. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>56<\/jats:bold>: 1164\u20131168, 2017<\/jats:p>","DOI":"10.1002\/mus.25669","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T21:09:53Z","timestamp":1493154593000},"page":"1164-1168","source":"Crossref","is-referenced-by-count":19,"title":["Finger extension weakness and downbeat nystagmus motor neuron disease syndrome: A novel motor neuron disorder?"],"prefix":"10.1002","volume":"56","author":[{"given":"Aline","family":"Delva","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospitals Leuven Campus Gasthuisberg, Herestraat 49, 3000 Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimish","family":"Thakore","sequence":"additional","affiliation":[{"name":"Department of Neurology Cleveland Clinic Foundation Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik P.","family":"Pioro","sequence":"additional","affiliation":[{"name":"Department of Neurology Cleveland Clinic Foundation Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Poesen","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Neurobiomarker Research University of Leuven (KU Leuven) Leuven Belgium"},{"name":"Laboratory Medicine University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Saunders\u2010Pullman","sequence":"additional","affiliation":[{"name":"Department of Neurology Mount Sinai Beth Israel and Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge A.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Neurology Mount Sinai Beth Israel and Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet C.","family":"Rucker","sequence":"additional","affiliation":[{"name":"Department of Neurology Mount Sinai Beth Israel and Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Kissel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wexner Medical Center Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Van Damme","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospitals Leuven Campus Gasthuisberg, Herestraat 49, 3000 Leuven Belgium"},{"name":"Department of Neurosciences University of Leuven (KU Leuven) Leuven Belgium"},{"name":"Laboratory of Neurobiology VIB Center for Brain &amp; 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