{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:40:08Z","timestamp":1740141608772,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:00:00Z","timestamp":1494806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371607","81571739"],"award-info":[{"award-number":["81371607","81571739"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The immune system plays a pivotal role in nerve injury. The aim of this study was to determine the role of multiparametric magnetic resonance imaging (MRI) in evaluation of the synergic effect of immunomodulation on nerve regeneration in neurotmesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rats with sciatic nerve neurotmesis and surgical repair underwent serial multiparametric MR examinations over an 8\u2010week period after subepineurial microinjection of lipopolysaccharide (LPS) and subsequent subcutaneous injection of FK506 or subepineurial microinjection of LPS or phosphate\u2010buffered saline (PBS) alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nerves treated with immunomodulation showed more prominent regeneration than those treated with LPS or PBS alone and more rapid restoration toward normal T2, fractional anisotropy (FA), and radial diffusivity (RD) values than nerves injected with LPS or PBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Nerves treated with immunomodulation exert synergic beneficial effects on nerve regeneration that can be predicted by T2 measurements and FA and RD values. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>57<\/jats:bold>: E38\u2013E45, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25674","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T23:56:54Z","timestamp":1493251014000},"source":"Crossref","is-referenced-by-count":3,"title":["Assessment of the synergic effect of immunomodulation on nerve repair using multiparametric magnetic resonance imaging"],"prefix":"10.1002","volume":"57","author":[{"given":"Chu\u2010Shan","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Radiology Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University No. 107 Yanjiang Road West, Guangzhou 510120 Guangdong 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