{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:23:57Z","timestamp":1760171037299},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> The aim of this study was to follow circulating brain\u2010derived neurotrophic factor (BDNF) and interleukin\u20106 (IL\u20106) levels in response to severe muscle\u2010damaging exercise. <jats:italic>Methods:<\/jats:italic> Young healthy men (<jats:italic>N<\/jats:italic> = 10) performed a bout of mechanically demanding stretch\u2013shortening cycle exercise consisting of 200 drop jumps. Voluntary and electrically induced knee extension torque, serum BDNF levels, and IL\u20106 levels were measured before and for up to 7 days after exercise. <jats:italic>Results:<\/jats:italic> Muscle force decreased by up to 40% and did not recover by 24 hours after exercise. Serum BDNF was decreased 1 hour and 24 hours after exercise, whereas IL\u20106 increased immediately and 1 hour after but recovered to baseline by 24 hours after exercise. IL\u20106 and 100\u2010Hz stimulation torque were correlated (<jats:italic>r<\/jats:italic> = \u22120.64, <jats:italic>P<\/jats:italic> &lt; 0.05) 24 hours after exercise. <jats:italic>Discussion:<\/jats:italic> In response to acute, severe muscle\u2010damaging exercise, serum BDNF levels decrease, whereas IL\u20106 levels increase and are associated with peripheral fatigue. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>57<\/jats:bold>: E46\u2013E51, 2018<\/jats:p>","DOI":"10.1002\/mus.25687","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T08:35:44Z","timestamp":1494664544000},"source":"Crossref","is-referenced-by-count":13,"title":["Serum brain\u2010derived neurotrophic factor and interleukin\u20106 response to high\u2010volume mechanically demanding exercise"],"prefix":"10.1002","volume":"57","author":[{"given":"Vaidas","family":"Verbickas","sequence":"first","affiliation":[{"name":"Institute of Sports Science and Innovation Lithuanian 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