{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:57:05Z","timestamp":1791593825064,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> For patients receiving intravenous immunoglobulin (IVIg), renal and hemolytic side effects are well recognized. However, there are very few data on the effects of chronic IVIg therapy. <jats:italic>Methods:<\/jats:italic> We retrospectively analyzed laboratory data on 166 patients who received IVIg for 12 months with a dose range of 0.441\u20132.58 g\/kg\/month, measuring changes in hematocrit and glomerular filtration (GFR) rates at 6 and 12 months. <jats:italic>Results:<\/jats:italic> Of the 2,232 infusions, there were no incidents of clinical hemolysis. However, after 12 months of treatment, 21% of patients had a \u22653\u2010g\/dl decline in hematocrit and 10% had a \u226520% decline in GFR. <jats:italic>Discussion:<\/jats:italic> No clinically significant hemolysis was observed in patients receiving chronic IVIg therapy. However, a significant number of patients had a decline in hematocrit and\/or GFR while on therapy. This emphasizes the need for observation of hematologic and renal function in patients treated with chronic IVIg. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>56<\/jats:bold>: 1173\u20131176, 2017<\/jats:p>","DOI":"10.1002\/mus.25693","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T12:45:39Z","timestamp":1495111539000},"page":"1173-1176","source":"Crossref","is-referenced-by-count":12,"title":["Renal and hematologic side effects of long\u2010term intravenous immunoglobulin therapy in patients with neurologic disorders"],"prefix":"10.1002","volume":"56","author":[{"given":"Aidan A.","family":"Levine","sequence":"first","affiliation":[{"name":"Phoenix Neurological Associates 5090 North 40th Street, Suite 250, Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd D.","family":"Levine","sequence":"additional","affiliation":[{"name":"Phoenix Neurological Associates 5090 North 40th Street, Suite 250, Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathie","family":"Clarke","sequence":"additional","affiliation":[{"name":"Phoenix Neurological Associates 5090 North 40th Street, Suite 250, Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Saperstein","sequence":"additional","affiliation":[{"name":"Phoenix Neurological Associates 5090 North 40th Street, Suite 250, Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24358"},{"key":"e_1_2_6_3_1","article-title":"Intravenous immunoglobulin for Guillain Barre syndrome","volume":"19","author":"Hughes RA","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000232"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2014.971757"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6_Suppl_5.S2"},{"key":"e_1_2_6_7_1","first-page":"6","article-title":"On the dark side of therapies with immunoglobulin concentrates: the adverse events","author":"Spath PJ","year":"2015","journal-title":"Front Immunol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354893"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5414\/CN106824"},{"key":"e_1_2_6_10_1","volume-title":"Carimune NF [package insert]","year":"2013"},{"key":"e_1_2_6_11_1","volume-title":"Bivigam [package insert]","year":"2012"},{"key":"e_1_2_6_12_1","volume-title":"Privigen [package insert]","year":"2007"},{"key":"e_1_2_6_13_1","volume-title":"Gamunex\u2010C [package insert]","year":"2015"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.09.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13198"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.09.012"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01721.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12833"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1310\/hpj4609-668"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2010.09.2214"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft128"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.25693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.25693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:16:23Z","timestamp":1695500183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.25693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,30]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/mus.25693"],"URL":"https:\/\/doi.org\/10.1002\/mus.25693","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,30]]}}}