{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:40:23Z","timestamp":1790991623036,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1K01HD084690\u201001A1 to J.M."],"award-info":[{"award-number":["1K01HD084690\u201001A1 to J.M."]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction<jats:sc>:<\/jats:sc><\/jats:italic>In this study we examined the feasibility of assessing motor milestone performance of infants with spinal muscular atrophy (SMA) using the Hammersmith Infant Neurological Exam\u2014Part 2 (HINE\u20102) in a phase 2 study of nusinersen.<jats:italic>Methods:<\/jats:italic>Nineteen SMA infants were assessed using the HINE\u20102 at baseline (\u22647 months of age), and periodically up to 39 months of age. We evaluated whether the HINE\u20102 was feasible, reliable, and sensitive to change.<jats:italic>Results:<\/jats:italic>Motor milestone assessments in SMA infants were feasible using the HINE\u20102. Baseline test\u2013retest reliability was excellent (<jats:italic>R<\/jats:italic>= 0.987;<jats:italic>P<\/jats:italic>&lt; 0.0001). SMA infants were extremely low functioning at baseline and the HINE\u20102 was able to detect changes over time in 16 of 19 infants within all 8 domains. HINE\u20102 improvements were correlated with changes in other neuromuscular outcome measures.<jats:italic>Conclusion:<\/jats:italic>Results support the use of the HINE\u20102 motor milestone assessment in clinical trials of SMA infants.<jats:italic>Muscle Nerve<\/jats:italic><jats:bold>57<\/jats:bold>: 143\u2013146, 2017<\/jats:p>","DOI":"10.1002\/mus.25705","type":"journal-article","created":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T01:02:49Z","timestamp":1495846969000},"page":"142-146","source":"Crossref","is-referenced-by-count":69,"title":["Motor milestone assessment of infants with spinal muscular atrophy using the hammersmith infant neurological Exam\u2014Part 2: Experience from a nusinersen clinical study"],"prefix":"10.1002","volume":"57","author":[{"given":"Kathie M.","family":"Bishop","sequence":"first","affiliation":[{"name":"Ionis Pharmaceuticals, Inc. Carlsbad California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Montes","sequence":"additional","affiliation":[{"name":"Departments of Rehabilitation and Regenerative Medicine and Neurology Columbia University Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Finkel","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Nemours Children's Hospital Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90460-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(200003)15:3<228::AID-HUMU3>3.0.CO;2-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2015.03.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540290108025"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000741"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.283"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.1984.tb00170.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20048"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70016-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.119626"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12876"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-924333"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2016.10.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.01.014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001777"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.212407"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31408-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2009.11.014"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20473"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1651-2227.2006.tb02379.x","article-title":"WHO Motor Development Study: windows of achievement for six gross motor development milestones","volume":"450","author":"WHO Multicenter Growth Reference Study Group","year":"2006","journal-title":"Acta Paediatr Suppl"},{"key":"e_1_2_7_22_1","first-page":"S46","article-title":"Construction and validation of the Alberta Infant Motor Scale (AIMS)","volume":"83","author":"Piper MC","year":"1992","journal-title":"Can J Public Health"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEP.0b013e318181ae96"},{"key":"e_1_2_7_24_1","volume-title":"Bayley scales of infant development","author":"Bayley N","year":"1993"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811420294"},{"key":"e_1_2_7_26_1","unstructured":"KuntzN for the ENDEAR Study Group.Nusinersen treatment of infantile\u2010onset spinal muscular atrophy (SMA): study design and initial interim efficacy and safety findings from the phase 3 ENDEAR study. World Muscle Society annual meeting Grenada Spain October2016 Neuromuscular Disorders Volume 26 Supplement 2 S49\u2013S230."},{"key":"e_1_2_7_27_1","unstructured":"U.S. Food and Drug Administration.FDA approves first drug for spinal muscular atrophy. December 23 2016.https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm534611.htm\/. 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