{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:54:53Z","timestamp":1788317693808,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Muscular Dystrophy Association Clinical Research Network"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Symptomatic management is the main focus of ALS clinical care. We aim to report the prevalence of ALS\u2010related symptoms and characterize self\u2010reported symptomatic management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A symptom management survey developed by the Muscular Dystrophy Association Clinical Research Network was completed by ALS registrants. Logistic regression identified potential predictors of symptom prevalence, severity, and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 567 ALS participants reported fatigue (90%), muscle stiffness (84%), and muscle cramps (74%) as most prevalent symptoms. Fatigue (18%), muscle stiffness (14%), and shortness of breath (12%) were most bothersome. Although fatigue was the most prevalent symptom, it was also least treated (10%). Neither location of care nor disease duration was associated with symptom prevalence, severity, or probability of receiving treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      This large patient\u2010reported symptom survey suggests that fatigue is the most prevalent, bothersome, and undertreated ALS symptom. Improving ALS symptom management is an unmet medical need and clinical trials of symptomatic treatments are needed.\n                      <jats:italic>Muscle Nerve<\/jats:italic>\n                      <jats:bold>57<\/jats:bold>\n                      : 20\u201324, 2018\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.25712","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T11:03:14Z","timestamp":1496228594000},"page":"20-24","source":"Crossref","is-referenced-by-count":56,"title":["Improving symptom management for people with amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"57","author":[{"given":"Katharine","family":"Nicholson","sequence":"first","affiliation":[{"name":"Harvard Medical School, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital 165 Cambridge St, Suite 600, Boston Massachusetts 02114 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