{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:40:03Z","timestamp":1740141603725,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005350","name":"Swedish National Centre for Research in Sports","doi-asserted-by":"publisher","award":["P2013\u20100093"],"award-info":[{"award-number":["P2013\u20100093"]}],"id":[{"id":"10.13039\/501100005350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> Muscle changes in patients with diabetes and lower leg pain due to chronic exertional compartment syndrome (CECS) were investigated before and after fasciotomy. <jats:italic>Methods:<\/jats:italic> The tibialis anterior muscle was analyzed with histochemical and morphological techniques in 7 patients with diabetes and CECS before fasciotomy and in 5 of them 1 year after fasciotomy. Nondiabetic patients with CECS and healthy participants served as references. <jats:italic>Results:<\/jats:italic> Before treatment, walking distance until occurrence of pain was limited (&lt;0.2 km). Intramuscular pressure was significantly higher than in reference participants. Muscle analysis showed changes pathognomonic for neuropathy and myopathy and a restricted capillary network, with significantly more severe changes in the muscles of patients with diabetes than in the muscles of nondiabetic patients. Treatment with fasciotomy improved clinical signs, increased walking ability, and reduced muscle abnormalities, but muscle capillarization remained low. <jats:italic>Discussion:<\/jats:italic> Patients with diabetes and CECS have distinct pathological changes in affected muscles. Pressure\u2010relieving fasciotomy triggers a regenerative response in the muscle tissue but not in the capillary bed. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>57<\/jats:bold>: 229\u2013239, 2018<\/jats:p>","DOI":"10.1002\/mus.25715","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T15:06:41Z","timestamp":1496243201000},"page":"229-239","source":"Crossref","is-referenced-by-count":2,"title":["Muscle changes in patients with diabetes and chronic exertional compartment syndrome before and after treatment with fasciotomy"],"prefix":"10.1002","volume":"57","author":[{"given":"David S.","family":"Edmundsson","sequence":"first","affiliation":[{"name":"Division of Orthopedics, Department of Surgery and Perioperative Science Ume\u00e5 University Hospital Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran L.","family":"Toolanen","sequence":"additional","affiliation":[{"name":"Division of Orthopedics, Department of Surgery and Perioperative Science Ume\u00e5 University Hospital Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9340-5298","authenticated-orcid":false,"given":"Per S.","family":"St\u00e5l","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle Biology, Department of Integrative Medical Biology Ume\u00e5 University 901 87 Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453670710015544"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.03158.x"},{"key":"e_1_2_7_4_1","first-page":"219","article-title":"Chronic exertional compartment syndrome of the lower leg","volume":"23","author":"Abramowitz AJ","year":"1994","journal-title":"Orthop Rev"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199315060-00005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198910000-00016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200003001-00002"},{"key":"e_1_2_7_8_1","first-page":"77","article-title":"Chronic exertional compartment syndrome: diagnosis and management","volume":"62","author":"Bong MR","year":"2005","journal-title":"Bull Hosp Jt Dis"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1302\/0301-620X.69B2.3818765","article-title":"Intramuscular pressure and muscle blood flow during exercise in chronic compartment syndrome","volume":"69","author":"Styf J","year":"1987","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2009.01013.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/036354659001800106"},{"key":"e_1_2_7_12_1","first-page":"90","article-title":"Perceived exertion: a note on \u201chistory\u201d and methods","volume":"5","author":"Borg GA","year":"1973","journal-title":"Med Sci Sports"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453670610013547"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.11.006"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2000.19720275.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540205000205"},{"key":"e_1_2_7_17_1","first-page":"28","volume-title":"Muscle biology. 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