{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:17:01Z","timestamp":1761718621095},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16ek0109056h0003","16ek0109115h0002"],"award-info":[{"award-number":["16ek0109056h0003","16ek0109115h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neurofascin155 (NF155) is a target antigen for autoantibodies in a subset of chronic inflammatory demyelinating polyneuropathy (CIDP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report the cases of 4 patients with anti\u2010NF155 immunoglobulin G4 (IgG4) antibody\u2010positive CIDP who underwent sural nerve biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients were relatively young at onset. Three patients experienced tremors, and 2 patients had severe ataxia. Although the response to intravenous immunoglobulin was poor in all patients, plasma exchange and corticosteroids were at least partially effective. Immunoadsorption plasmapheresis was performed in 1 patient but was ineffective. Electron microscopic examination of sural nerve biopsies revealed loss of paranodal transverse bands in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Anti\u2010NF155 IgG4 antibody\u2010positive CIDP shows distinctive clinicopathological features, indicating that the IgG4 antibody is directly associated with the pathogenic mechanisms of anti\u2010NF155 IgG4 antibody\u2010positive CIDP. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>57<\/jats:bold>: 498\u2013502, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25757","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T11:16:52Z","timestamp":1502363812000},"page":"498-502","source":"Crossref","is-referenced-by-count":28,"title":["ELectron microscopic abnormality and therapeutic efficacy in chronic inflammatory demyelinating polyneuropathy with anti\u2010neurofascin155 immunoglobulin G4 antibody"],"prefix":"10.1002","volume":"57","author":[{"given":"Motoi","family":"Kuwahara","sequence":"first","affiliation":[{"name":"Department of Neurology Kindai University Faculty of Medicine 377\u20102 Ohno\u2010Higashi, Osaka\u2010Sayama Osaka 589\u20108511 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurology Kindai University Faculty of Medicine 377\u20102 Ohno\u2010Higashi, Osaka\u2010Sayama Osaka 589\u20108511 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Neurology National Hospital Organization Minami\u2010Kyoto Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurological Institute, Graduate School of Medical Sciences, Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yanagimoto","sequence":"additional","affiliation":[{"name":"Department of Neurology Kindai University Faculty of Medicine 377\u20102 Ohno\u2010Higashi, Osaka\u2010Sayama Osaka 589\u20108511 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Sadakane","sequence":"additional","affiliation":[{"name":"Department of Neurology Kindai University Faculty of Medicine 377\u20102 Ohno\u2010Higashi, Osaka\u2010Sayama Osaka 589\u20108511 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Department of Neurology Kindai University Faculty of Medicine 377\u20102 Ohno\u2010Higashi, Osaka\u2010Sayama Osaka 589\u20108511 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Kindai University Faculty of Medicine 377\u20102 Ohno\u2010Higashi, Osaka\u2010Sayama Osaka 589\u20108511 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Neurology Kindai University Faculty of Medicine 377\u20102 Ohno\u2010Higashi, Osaka\u2010Sayama Osaka 589\u20108511 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Neurology Kindai University Faculty of Medicine 377\u20102 Ohno\u2010Higashi, Osaka\u2010Sayama Osaka 589\u20108511 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagahama City Hospital Shiga 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