{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:46:44Z","timestamp":1789944404036,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:00:00Z","timestamp":1503619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients with Duchenne muscular dystrophy (DMD) frequently undergo mechanical ventilation (MV) for treatment of hypoventilation, but the susceptibility of the dystrophic diaphragm to ventilator\u2010induced diaphragmatic dysfunction (VIDD) has not been examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dystrophic mice (<jats:italic>mdx<\/jats:italic>\u2014genetic homolog of DMD) were assigned to non\u2010ventilated control (CTL) and MV (for 6 hours) groups. Biochemical markers of oxidative\/cellular stress, metabolism, and proteolysis were compared along with <jats:italic>ex\u2010vivo<\/jats:italic> diaphragmatic force production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MV significantly depressed maximal diaphragmatic force production compared with baseline values. In addition, MV triggered oxidative stress responses, STAT3 phosphorylation, and an upregulation of cellular pathways associated with muscle proteolysis and\/or wasting (autophagy, E3 ubiquitin ligases, and myostatin).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Short\u2010term MV induces rapid diaphragmatic force loss and biochemical changes consistent with VIDD in <jats:italic>mdx<\/jats:italic> mice. This may have implications for the optimal use of intermittent MV in DMD patients. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>57<\/jats:bold>: 442\u2013448, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25760","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T08:26:39Z","timestamp":1502180799000},"page":"442-448","source":"Crossref","is-referenced-by-count":14,"title":["Ventilator\u2010induced diaphragmatic dysfunction in <i>MDX<\/i> mice"],"prefix":"10.1002","volume":"57","author":[{"given":"Feng","family":"Liang","sequence":"first","affiliation":[{"name":"Meakins\u2010Christie Laboratories, and Translational Research in Respiratory Diseases Program McGill University Health Centre and Research Institute 1001 Decarie Boulevard, Montreal Quebec H4A 3J1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[{"name":"Meakins\u2010Christie Laboratories, and Translational Research in Respiratory Diseases Program McGill University Health Centre and Research Institute 1001 Decarie Boulevard, Montreal Quebec H4A 3J1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Azuelos","sequence":"additional","affiliation":[{"name":"Meakins\u2010Christie Laboratories, and Translational Research in Respiratory Diseases Program McGill University Health Centre and Research Institute 1001 Decarie Boulevard, Montreal Quebec H4A 3J1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Giordano","sequence":"additional","affiliation":[{"name":"Meakins\u2010Christie Laboratories, and Translational Research in Respiratory Diseases Program McGill University Health Centre and Research Institute 1001 Decarie Boulevard, Montreal Quebec H4A 3J1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Computational Biology University of Texas MD Anderson Cancer Center Houston Texas USA"},{"name":"Department of Systems Biology University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabah N.","family":"Hussain","sequence":"additional","affiliation":[{"name":"Meakins\u2010Christie Laboratories, and Translational Research in Respiratory Diseases Program McGill University Health Centre and Research Institute 1001 Decarie Boulevard, Montreal Quebec H4A 3J1 Canada"},{"name":"Department of Critical Care McGill University Health Centre Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Matecki","sequence":"additional","affiliation":[{"name":"Pediatric Functional Exploration Unit University 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