{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:49:06Z","timestamp":1767649746472,"version":"3.37.3"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI12C0135"],"award-info":[{"award-number":["HI12C0135"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Mesenchymal stem cells (MSCs) can differentiate into various cell types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study we investigated the potential of human tonsil\u2013derived MSCs (T\u2010MSCs) for neuromuscular regeneration in <jats:italic>trembler<\/jats:italic>\u2010<jats:italic>J<\/jats:italic> (Tr\u2010J) mice, a model for Charcot\u2013Marie\u2013Tooth disease type 1A (CMT1A).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>T\u2010MSCs differentiated toward skeletal myocytes with increased expression of skeletal muscle\u2013related markers (including troponin I type 1, and myogenin), and the formation of myotubes <jats:italic>in vitro. In\u2010situ<\/jats:italic> transplantation of T\u2010MSC\u2013derived myocytes (T\u2010MSC myocytes) into the gastrocnemius muscle in Tr\u2010J mice enhanced motor function, with recovery of compound muscle action potential amplitudes. Morphology of the sciatic nerve and skeletal muscle recovered without the formation of teratomas, and the expression levels of nerve growth factor and glial\u2010cell\u2010line\u2013derived neurotrophic factor were increased significantly in T\u2010MSC myocytes compared with T\u2010MSCs <jats:italic>in vitro<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Transplantation of T\u2010MSC myocytes could enable neuromuscular regeneration in patients with CMT1A. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>57<\/jats:bold>: 478\u2013486, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25763","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T11:32:46Z","timestamp":1502364766000},"page":"478-486","source":"Crossref","is-referenced-by-count":8,"title":["Application of differentiated human tonsil\u2013derived stem cells to <i>trembler\u2010J<\/i> mice"],"prefix":"10.1002","volume":"57","author":[{"given":"Saeyoung","family":"Park","sequence":"first","affiliation":[{"name":"Department of Biochemistry, College of Medicine Ewha Womans University 1071 Anyangcheon\u2010Ro, Yangcheon\u2010Gu, Seoul 07985 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoonyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine Ewha Womans University 1071 Anyangcheon\u2010Ro, Yangcheon\u2010Gu, Seoul 07985 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geon","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Technology Sungkyunkwan University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Bin","family":"Hong","sequence":"additional","affiliation":[{"name":"Stem Cell &amp; Regenerative Medicine Institute, Samsung Medical Center 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