{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:54:36Z","timestamp":1793915676347,"version":"4.8.0"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In this study we determined the clinical, paraclinical, and treatment\u2010related features of juvenile myasthenia gravis (JMG) as well as the clinical course in a cohort of French children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study of 40 patients with JMG at 2 French pediatric neurology departments from April 2004 to April 2014.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the patients, 70% had generalized JMG, 52% had positive acetylcholine receptor antibodies, 8% had muscle\u2010specific kinase antibodies, and 40% were seronegative. Treatment with acetylcholinesterase inhibitors was effective and sufficient in 47% of patients. The 6 patients with generalized JMG treated with rituximab and\/or immunoadsorption showed improvement. Thirty percent of the patients required hospitalization in an intensive care unit during follow\u2010up (mean 4.7 years). Remission without treatment occurred in 18% of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      As with adults, JMG has high morbidity, particularly among children with generalized symptoms, and rituximab should be considered early in the course of the disease as a second\u2010line treatment.\n                      <jats:italic>Muscle Nerve<\/jats:italic>\n                      <jats:bold>57<\/jats:bold>\n                      : 603\u2013609, 2018\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.25965","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T17:42:57Z","timestamp":1504719777000},"page":"603-609","source":"Crossref","is-referenced-by-count":35,"title":["Clinical features and evolution of juvenile myasthenia gravis in a French 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