{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:50:53Z","timestamp":1771030253485,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:00:00Z","timestamp":1507248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","award":["14\/TPG\/1\u201005"],"award-info":[{"award-number":["14\/TPG\/1\u201005"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Muscle wasting is a frequent, debilitating complication of cancer. The impact of colorectal cancer chemotherapeutic oxaliplatin on the development of muscle loss and associated molecular changes is of clinical importance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>C57BL\/6J male mice were treated with oxaliplatin. Total body weights were measured and behavioral studies performed. Hindlimb muscle weights (gastrocnemius and soleus) were recorded in conjunction with gene and protein expression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Oxaliplatin\u2010treated mice displayed reduced weight gain and behavioral deficits. Mice treated over a shorter course had significantly increased STAT3 phosphorylation in gastrocnemius muscles. Mice receiving extended oxaliplatin treatment demonstrated reduced hindlimb muscle mass with upregulation of myopathy\u2010associated genes <jats:italic>Foxo3, MAFbx<\/jats:italic>, and <jats:italic>Bnip3<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The findings suggest that oxaliplatin treatment can directly disrupt skeletal muscle homeostasis and promote muscle loss, which may be clinically relevant in the context of targeting fatigue and weakness in cancer patients. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>57<\/jats:bold>: 650\u2013658, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.25966","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T19:43:06Z","timestamp":1504813386000},"page":"650-658","source":"Crossref","is-referenced-by-count":25,"title":["Oxaliplatin induces muscle loss and muscle\u2010specific molecular changes in Mice"],"prefix":"10.1002","volume":"57","author":[{"given":"Claire E.","family":"Feather","sequence":"first","affiliation":[{"name":"School of Medical Sciences University of New South Wales Sydney New South Wales 2052 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin G.","family":"Lees","sequence":"additional","affiliation":[{"name":"School of Medical Sciences University of New South Wales Sydney New South Wales 2052 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preet G.S.","family":"Makker","sequence":"additional","affiliation":[{"name":"School of Medical Sciences University of New South Wales Sydney New South Wales 2052 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School University of New South Wales Sydney New South Wales 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