{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:39:51Z","timestamp":1740141591231,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T00:00:00Z","timestamp":1506729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> Given recent findings of subclinical sensory deficits in colorectal cancer patients before oxaliplatin treatment, in the current study we aimed to identify evidence of subclinical peripheral neuropathy on multimodal testing before chemotherapy commencement. <jats:italic>Methods:<\/jats:italic> Clinical, functional, and neurophysiological assessments were undertaken in 93 colorectal cancer patients before chemotherapy. <jats:italic>Results:<\/jats:italic> There was no neurophysiological evidence of neuropathy, with 92 of 93 sural sensory values within normative reference values for age and no significant abnormalities detected in nerve conduction or nerve excitability studies. Clinical neurological assessment revealed 75.9% of patients with no signs or symptoms, 10.3% with reduction in distal vibration or pinprick sensitivity, and 6.9% with reduction in ankle reflexes only. There was no difference in manual dexterity (using the 9\u2010hole peg\u2010board test) compared with normative data. <jats:italic>Discussion:<\/jats:italic> The present study has established a low likelihood of significant distal symmetrical polyneuropathy in colorectal cancer patients before initiation of chemotherapy. <jats:italic>Muscle Nerve<\/jats:italic> <jats:bold>57<\/jats:bold>: 615\u2013621, 2018<\/jats:p>","DOI":"10.1002\/mus.25968","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T19:38:59Z","timestamp":1504813139000},"page":"615-621","source":"Crossref","is-referenced-by-count":2,"title":["Multimodal quantitative examination of nerve function in colorectal cancer patients prior to chemotherapy"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4355-4965","authenticated-orcid":false,"given":"Tejaswi","family":"Kandula","sequence":"first","affiliation":[{"name":"School of Women's and Children's Health, UNSW Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle A.","family":"Farrar","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health, UNSW Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun V.","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School, UNSW Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Murray","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School, UNSW Medicine University of New South Wales Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah C.","family":"Timmins","sequence":"additional","affiliation":[{"name":"Brain &amp; 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